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Published on: June 2, 2023
Phthalates: European regulation, chemistry, pharmacokinetic and related toxicity
Pasquale Ventrice1, Domenica Ventrice, Emilio Russo
1Chair of Pharmacology, Science of Health Department, School of Medicine, University of Catanzaro, Italy.
Abstract:
Phthalates are chemicals widely used in industry and the consequences for human health caused by exposure to these agents are of significant current interest. Phthalate toxicity targets the reproductive and respiratory systems primarily, but they also may be involved in the processes of carcinogenesis and even in autism spectrum disorders. This article discusses the molecular and cellular mechanisms involved in organ toxicity of phthalates; furthermore, pharmacokinetic, chemistry and the European regulation are summarized.
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