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[Brain stem dysfunction in Arnold-Chiari II syndrome].

A M Holschneider1, J A Bliesener, M Abel

  • 1Kinderchirurgische Klinik, Städtischen Kinderkrankenhauses Köln.

Zeitschrift Fur Kinderchirurgie : Organ Der Deutschen, Der Schweizerischen Und Der Osterreichischen Gesellschaft Fur Kinderchirurgie = Surgery in Infancy and Childhood
|April 1, 1990
PubMed
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Arnold-Chiari II syndrome can cause brain stem issues in myelomeningocele patients. Early intervention for symptoms like stridor is crucial for better outcomes.

Area of Science:

  • Neurology
  • Pediatrics
  • Developmental Biology

Context:

  • Myelomeningocele is a severe birth defect impacting the spinal cord and brain.
  • Arnold-Chiari II malformation is a common complication associated with myelomeningocele.
  • Brain stem dysfunction can arise as a sequel to Arnold-Chiari II malformation.

Purpose:

  • To analyze the clinical presentation and outcomes of brain stem signs in pediatric patients with myelomeningocele and Arnold-Chiari II malformation.
  • To propose a refined classification system for brain stem signs based on observed symptom combinations.

Summary:

  • This study reviewed 76 myelomeningocele patients, identifying 12 with brain stem signs linked to Arnold-Chiari II syndrome.
  • Observed signs included stridor, apnea, and dysphagia, occurring in various combinations.

Related Experiment Videos

  • A proposed three-grade classification highlights that the presence of all three signs (Grade III) indicates a poor prognosis, with 6 of 12 affected patients dying.

    • Impact:

    • The findings suggest that stridor in myelomeningocele patients warrants consideration of Arnold-Chiari malformation.
    • Early diagnosis and surgical intervention, such as shunt revision, may improve patient prognosis.
    • This research contributes to a better understanding of brain stem dysfunction in pediatric neurological conditions.