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Updated: May 12, 2026
12:22
A Primary Neuron Culture System for the Study of Herpes Simplex Virus Latency and Reactivation
Published on: April 2, 2012
Herpes simplex virus reactivation and dental procedures.
L El Hayderi1, P Delvenne, E Rompen
1Department of Dermatology, University Medical Center Liège, 4000, Liège, Belgium.
Clinical Oral Investigations
|April 23, 2013
Summary
Dental procedures, especially molar extraction, may increase oral herpes simplex virus type 1 (HSV-1) shedding but do not trigger recurrent herpes labialis (RHL). Antiviral prophylaxis is not routinely recommended for dental procedures.
Area of Science:
- Oral medicine
- Virology
- Dental surgery
Background:
- Recurrent herpes labialis (RHL) is sometimes triggered by dental extraction.
- Herpes simplex virus type 1 (HSV-1) is the common cause of RHL.
Purpose of the Study:
- To prospectively investigate the clinical occurrence of RHL and oral HSV-1 viral shedding.
- To compare these occurrences after various dental procedures.
Main Methods:
- 57 immunocompetent patients undergoing dental procedures were studied.
- Oral HSV-1 DNA was measured by real-time PCR before and 3 days after procedures.
- Patients were grouped by procedure type: inspection, filling, local anesthesia extraction, general anesthesia extraction.
Main Results:
- No patients developed RHL 3 days post-procedure.
- Oral HSV-1 DNA was detected in 5.3% of patients post-procedure, with higher rates after extractions.
- No significant difference in RHL or HSV-1 shedding was found compared to controls.
Conclusions:
- Molar extraction increases the risk of oral HSV-1 shedding, likely due to procedure-related nerve damage causing HSV reactivation.
- Routine antiviral prophylaxis for RHL is not recommended for dental procedures.
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