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11:17
Comparative Analysis of Human Growth Hormone in Serum Using SPRi, Nano-SPRi and ELISA Assays
Published on: January 7, 2016
Growth hormone and aging
A Bartke1, H Brown-Borg, B Kinney
1Department of Physiology, Southern Illinois University, School of Medicine, Carbondale, IL 62901-6512.
Journal of the American Aging Association
|April 23, 2013
Summary
Growth hormone (GH) impacts aging. While GH decline causes aging symptoms, excessive GH shortens lifespan, suggesting GH
Area of Science:
- Endocrinology
- Gerontology
- Molecular Biology
Background:
- Growth hormone (GH) secretion decreases with age.
- GH administration can reverse age-related body composition changes.
- GH's role in aging is complex and paradoxical.
Purpose of the Study:
- To investigate the dual role of growth hormone (GH) in aging and lifespan.
- To explore the relationship between GH levels, body composition, and longevity.
Main Methods:
- Analysis of GH-deficient and GH-resistant mouse models.
- Comparison of lifespan and age-related changes in these models versus normal siblings.
- Review of existing literature on GH levels and life expectancy in mice and humans.
Main Results:
- GH-deficient and GH-resistant mice exhibit extended lifespans.
- Pathological elevation of GH levels is associated with reduced life expectancy.
- Age-related GH decline correlates with aging symptoms.
Conclusions:
- GH's influence on growth, development, and body size are key determinants of aging and lifespan.
- Reduced GH levels contribute to the physiological manifestations of aging.
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