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Related Experiment Video

Updated: May 12, 2026

Comparative Analysis of Human Growth Hormone in Serum Using SPRi, Nano-SPRi and ELISA Assays

Comparative Analysis of Human Growth Hormone in Serum Using SPRi, Nano-SPRi and ELISA Assays

Published on: January 7, 2016

Growth hormone and aging.

A Bartke¹, H Brown-Borg, B Kinney

¹Department of Physiology, Southern Illinois University, School of Medicine, Carbondale, IL 62901-6512.

Journal of the American Aging Association

|April 23, 2013

Summary

This summary is machine-generated.

Growth hormone (GH) impacts aging. While GH decline causes aging symptoms, excessive GH shortens lifespan, suggesting GH

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Exploring Independent Effects of Follicle-Stimulating Hormone In Vivo in a Mouse Model

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Published on: August 11, 2023

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Last Updated: May 12, 2026

Comparative Analysis of Human Growth Hormone in Serum Using SPRi, Nano-SPRi and ELISA Assays

Comparative Analysis of Human Growth Hormone in Serum Using SPRi, Nano-SPRi and ELISA Assays

Published on: January 7, 2016

Exploring Independent Effects of Follicle-Stimulating Hormone In Vivo in a Mouse Model

Exploring Independent Effects of Follicle-Stimulating Hormone In Vivo in a Mouse Model

Published on: August 11, 2023

Area of Science:

Endocrinology
Gerontology
Molecular Biology

Background:

Growth hormone (GH) secretion decreases with age.
GH administration can reverse age-related body composition changes.
GH's role in aging is complex and paradoxical.

Purpose of the Study:

To investigate the dual role of growth hormone (GH) in aging and lifespan.
To explore the relationship between GH levels, body composition, and longevity.

Main Methods:

Analysis of GH-deficient and GH-resistant mouse models.
Comparison of lifespan and age-related changes in these models versus normal siblings.
Review of existing literature on GH levels and life expectancy in mice and humans.

Main Results:

GH-deficient and GH-resistant mice exhibit extended lifespans.
Pathological elevation of GH levels is associated with reduced life expectancy.
Age-related GH decline correlates with aging symptoms.

Conclusions:

GH's influence on growth, development, and body size are key determinants of aging and lifespan.
Reduced GH levels contribute to the physiological manifestations of aging.