Related Experiment Video
Updated: May 12, 2026

Formation of Dispersible Taohong Siwu Tablets
Published on: February 3, 2023
Functionalized calcium carbonate as a novel pharmaceutical excipient for the preparation of orally dispersible
Tanja Stirnimann1, Nicola Di Maiuta, Daniel E Gerard
1Department of Pharmaceutical Science Division of Pharmaceutical Technology, University Basel, Klingelbergstrasse 50, 4056 Basel, Switzerland.
Purpose:
To overcome the limitation of insufficient hardness during the production of rapidly disintegrating orally dispersible tablets (ODTs). Furthermore, we investigated the properties and usefulness of functionalized calcium carbonate (FCC) as a new pharmaceutical excipient for the production of ODTs.
Methods:
A highly sensitive tensiometer-based method was developed to measure kinetics of weight loss during tablet disintegration. With this method we were able to determine the residence time of tablets placed on a basket immersed into a test medium. The shapes of tensiometer plots allowed us to categorize substances into four different types of disintegration.
Results:
At the same volume and hardness, the tablet formulations with FCC showed a significantly higher porosity (over 60%) than all other formulations. Residence time depended mainly on the tablet composition rather than on porosity. When combined with disintegrants, FCC formulations exhibited favorable disintegration properties, comparable to those of the marketed drug risperidone oro (disintegration time ca. 10 s).
Conclusions:
Oral dosage forms--based on the new pharmaceutical excipient FCC--can be designed to have a short disintegration time combined with good mechanical strength. Due to these properties, FCC can be used for the preparation of ODTs.
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