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Related Experiment Video

Updated: May 12, 2026

SCAnED - An Open-source Skin Segmentation Macro for Semi-automated Cell and Nuclei Detection in Epidermal and Dermal Skin Compartments

SCAnED - An Open-source Skin Segmentation Macro for Semi-automated Cell and Nuclei Detection in Epidermal and Dermal Skin Compartments

Published on: August 8, 2025

hMena: altered expression in psoriatic skin.

G Cardinali¹, D Kovacs, A Mastrofrancesco

¹Laboratory of Cutaneous Physiopathology and Integrated Center of Metabolomics Research, San Gallicano Dermatologic Institute (IRCCS), Via Elio Chianesi 53, 00144, Rome, Italy, cardinali@ifo.it.

Archives of Dermatological Research

|April 23, 2013

Summary

Human Mena (hMena) protein, typically found in tumors, is newly identified in psoriatic skin. Its expression correlates with keratinocyte proliferation and activation in psoriasis.

Related Experiment Videos

Last Updated: May 12, 2026

SCAnED - An Open-source Skin Segmentation Macro for Semi-automated Cell and Nuclei Detection in Epidermal and Dermal Skin Compartments

SCAnED - An Open-source Skin Segmentation Macro for Semi-automated Cell and Nuclei Detection in Epidermal and Dermal Skin Compartments

Published on: August 8, 2025

Area of Science:

Dermatology
Molecular Biology
Cell Biology

Background:

Psoriasis is a chronic inflammatory skin condition marked by keratinocyte hyperproliferation and abnormal differentiation.
The actin regulatory protein, human Mena (hMena), is implicated in cell motility and adhesion, and is upregulated in various human cancers.
hMena expression in cancer correlates with proliferation, tumor size, and aggressiveness.

Purpose of the Study:

To investigate hMena expression in psoriatic skin.
To determine if hMena is associated with keratinocyte hyperproliferation and activation in psoriasis.
To explore hMena's potential role in the pathogenesis of psoriasis.

Main Methods:

Analysis of hMena expression at transcript and protein levels using quantitative RT-PCR and immunohistochemistry.
Biopsies were collected from involved and uninvolved skin of 12 plaque-type psoriasis patients and healthy controls.
Correlation of hMena expression with Ki67 proliferation index, keratin 10 (K10), and keratin 16 (K16).

Main Results:

hMena is not expressed in healthy skin.
hMena expression is detected in non-lesional psoriatic skin and is significantly higher in lesional psoriatic skin.
hMena expression positively correlates with keratinocyte proliferation and activation markers (Ki67, K16).

Conclusions:

hMena is expressed in psoriatic skin, a hyperproliferative condition unrelated to cancer.
hMena expression is upregulated in psoriatic lesions compared to healthy skin.
hMena may play a role in the development and maintenance of psoriatic keratinocyte hyperproliferation.