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High-throughput Fluorometric Measurement of Potential Soil Extracellular Enzyme Activities
12:33

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Published on: November 15, 2013

[Not Available].

T Dillenburger1, U Lauber, M Schollenberger

  • 1Institut für Tierernährung (450), Universität Hohenheim, Emil-Wolff-Str. 10, 70599, Stuttgart, Deutschland.

Mycotoxin Research
|April 23, 2013
PubMed
Summary
This summary is machine-generated.

The minimum effective dose of deoxynivalenol (DON) for significant weight loss and reduced feed intake was not definitively established. Effects were observed only with naturally contaminated wheat under ad libitum feeding conditions.

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Area of Science:

  • Animal Nutrition
  • Toxicology
  • Food Safety

Context:

  • Deoxynivalenol (DON) is a common mycotoxin in grains, posing risks to animal health and productivity.
  • Understanding DON's effects requires controlled studies using both contaminated feed and pure toxin.
  • Previous research has not fully elucidated the minimum effective dose across different dietary matrices.

Purpose:

  • To determine the minimum effective dose of pure deoxynivalenol (DON) that causes measurable losses in weight gain and feed consumption.
  • To compare the effects of DON in naturally contaminated wheat versus a pure DON-spiked non-cereal (potato) diet.
  • To evaluate the impact of DON on blood parameters in addition to growth performance.

Summary:

  • Three feeding trials investigated DON's effects at concentrations of 4000 and 6000 µg/kg.
  • Significant reductions in feed consumption and weight gain were observed exclusively in the second trial, involving naturally contaminated wheat with ad libitum access.
  • No significant differences in weight gain, feed consumption, or blood parameters were detected in the first trial (restricted feeding) or the third trial (potato-based diet with pure DON).

Impact:

  • This study highlights the complexity of DON toxicity, influenced by dietary composition and feeding levels.
  • Findings suggest that naturally contaminated feed matrices and ad libitum feeding may increase susceptibility to DON's adverse effects.
  • Further research is needed to establish precise DON toxicity thresholds and understand interactions with different feed ingredients.