Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Acute Kidney Injury IV: Diagnostic Studies and Prevention

Acute Kidney Injury IV: Diagnostic Studies and Prevention

Accurate diagnosis and effective prevention are critical in managing Acute Kidney Injury (AKI), which is linked to high mortality rates ranging from 10% to 80%. Timely recognition of at-risk patients and careful monitoring can significantly reduce the likelihood of kidney damage.Diagnostic Assessments:The diagnostic process starts with a comprehensive medical history to identify prerenal, intrarenal, and postrenal causes.Prerenal causes, such as dehydration, hypotension, or blood loss, should...

Renal Failure: Dose Adjustments

Renal Failure: Dose Adjustments

In patients with renal impairment, drugs undergo significant changes in their pharmacokinetics, which require dosage adjustments to ensure safe and effective therapy.
Reduced renal clearance and elimination rate are common outcomes of renal impairment. These alterations lead to a prolonged elimination half-life and an altered apparent volume of distribution for drugs. As a result, dosage adjustments are typically necessary to maintain optimal drug levels in the body.
However, dosage adjustments...

Acute Kidney Injury V: Interprofessional Care

Acute Kidney Injury V: Interprofessional Care

Acute Kidney Injury (AKI) requires a collaborative healthcare approach to restore renal function and prevent complications. Essential management strategies involve monitoring fluid and electrolyte balance, adjusting medications, initiating dialysis when necessary, and providing nutritional support.Fluid and Electrolyte ManagementFluid Monitoring: Regularly monitoring body weight, central venous pressure, and urine output helps detect fluid imbalances early. Patient intake and output are...

Chronic Kidney Disease III: Interprofessional Care

Chronic Kidney Disease III: Interprofessional Care

Chronic kidney disease (CKD) requires collaborative and comprehensive management. CKD progresses through stages and can lead to end-stage kidney disease (ESKD) if untreated. Interprofessional collaboration and patient education are crucial, enabling patients to manage their health and improve their quality of life.Diagnostic approach for chronic kidney diseaseThe diagnosis of CKD primarily focuses on the glomerular filtration rate (GFR), which assesses kidney function by measuring how well...

Kidney Transplant II: Surgical Procedure

Kidney Transplant II: Surgical Procedure

Preoperative ManagementThe primary goals of preoperative management in kidney transplantation are to optimize the patient’s metabolic state and prepare them for surgery through diet adjustments, necessary dialysis, and tailored medical treatment. This phase also involves comprehensive infection screening and patient education about the surgical procedure and postoperative care to improve outcomes and adherence.Medical ManagementA comprehensive evaluation is required for both the living donor...

Acute Kidney Injury I: Introduction

Acute Kidney Injury I: Introduction

Introduction:Acute Kidney Injury (AKI) describes a swift decrease in kidney function occurring over hours to days, characterized by the kidneys' failure to remove waste products from the bloodstream. This leads to dangerous complications like metabolic acidosis, fluid overload, and electrolyte imbalances, such as hyperkalemia, which can cause life-threatening arrhythmias. AKI is common in both hospital and outpatient settings, often triggered by dehydration, sepsis, or exposure to nephrotoxic...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

We Cannot Overcome the Mediocrity of Colistin.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America·2025

Same author

Navigating the Muddled Middle: A Case-Based Exploration of Oral β-Lactams for Systemic Gram-Negative Infections.

Open forum infectious diseases·2025

Same author

Capivasertib plus fulvestrant in patients with HR-positive/HER2-negative advanced breast cancer: phase 3 CAPItello-291 study extended Chinese cohort.

Nature communications·2025

Same author

Antimicrobial Stewardship and Beyond: The Many Essential Roles of Infectious Diseases Pharmacists.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America·2025

Same author

A rapid cycle analytics framework for vaccine safety surveillance within a real-world data network: Experience with enhanced surveillance of the Janssen COVID-19 vaccine.

Vaccine·2025

Same author

Reply: "Continuing the Chat: How Can We Improve the Performance of an Artificial Intelligence Chatbot in Answering Clinical Infectious Diseases Pharmacotherapy Questions?"

Open forum infectious diseases·2025

Search research articles

Related Experiment Video

Updated: May 12, 2026

Antimicrobial Synergy Testing by the Inkjet Printer-assisted Automated Checkerboard Array and the Manual Time-kill Method

Antimicrobial Synergy Testing by the Inkjet Printer-assisted Automated Checkerboard Array and the Manual Time-kill Method

Published on: April 18, 2019

Emergent renal dysfunction with colistin pharmacotherapy.

Julie M Collins¹, Kevin Haynes, Jason C Gallagher

¹Temple University Hospital, Philadelphia, Pennsylvania, USA.

Pharmacotherapy

|April 23, 2013

Summary

Intravenous colistin use frequently caused renal dysfunction in critically ill patients. Older age and concurrent nephrotoxin administration were significant risk factors for developing kidney injury.

Keywords:

Acinetobacter colistin gram-negative multidrug-resistant polymyxin

More Related Videos

Acute Kidney Injury Model Induced by Cisplatin in Adult Zebrafish

Acute Kidney Injury Model Induced by Cisplatin in Adult Zebrafish

Published on: May 15, 2021

Related Experiment Videos

Last Updated: May 12, 2026

Antimicrobial Synergy Testing by the Inkjet Printer-assisted Automated Checkerboard Array and the Manual Time-kill Method

Antimicrobial Synergy Testing by the Inkjet Printer-assisted Automated Checkerboard Array and the Manual Time-kill Method

Published on: April 18, 2019

Acute Kidney Injury Model Induced by Cisplatin in Adult Zebrafish

Acute Kidney Injury Model Induced by Cisplatin in Adult Zebrafish

Published on: May 15, 2021

Area of Science:

Nephrology
Infectious Diseases
Critical Care Medicine

Background:

Intravenous (IV) colistin is crucial for treating multidrug-resistant Gram-negative infections.
Renal dysfunction is a known adverse effect of colistin, necessitating careful monitoring.
Understanding risk factors for colistin-induced nephrotoxicity is vital for patient management.

Purpose of the Study:

To evaluate the association between IV colistin administration and the incidence of renal dysfunction.
To identify risk factors contributing to colistin-related nephrotoxicity in critically ill patients.

Main Methods:

Retrospective medical record review of 174 critically ill patients receiving IV colistin.
Renal dysfunction defined as a ≥50% increase in serum creatinine or initiation of renal replacement therapy (RRT).
Logistic regression analysis to identify associations between clinical characteristics and renal dysfunction.

Main Results:

48% of patients (84/174) developed renal dysfunction during colistin therapy.
Multivariate analysis identified older age (OR 1.03, 95% CI 1.01-1.05) as a risk factor.
Concurrent administration of nephrotoxic agents significantly increased the risk of renal dysfunction (OR 3.35, 95% CI 1.34-8.36).

Conclusions:

Renal dysfunction is a frequent complication of IV colistin in critically ill patients.
Older age and concomitant nephrotoxin exposure are significant risk factors for colistin-induced renal injury.
Clinical vigilance and risk factor assessment are essential when prescribing IV colistin.