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Continuous Flow Chemistry: Reaction of Diphenyldiazomethane with p-Nitrobenzoic Acid

Continuous Flow Chemistry: Reaction of Diphenyldiazomethane with p-Nitrobenzoic Acid

Published on: November 15, 2017

Novel process windows for enabling, accelerating, and uplifting flow chemistry.

Volker Hessel¹, Dana Kralisch, Norbert Kockmann

¹Department of Chemical Engineering and Chemistry, Micro Flow Chemistry and Process Technology, Eindhoven University of Technology, PO BOX 513, 5600 MB Eindhoven, The Netherlands. v.hessel@tue.nl

|April 23, 2013

Summary

Novel Process Windows utilize extreme conditions like high temperatures and pressures for enhanced synthetic chemistry. Microstructured reactors enable these harsh conditions safely, boosting lab and production scales.

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Millifluidics for Chemical Synthesis and Time-resolved Mechanistic Studies

Millifluidics for Chemical Synthesis and Time-resolved Mechanistic Studies

Published on: November 27, 2013

Area of Science:

Chemical Engineering
Process Chemistry
Reaction Engineering

Background:

Conventional synthetic chemistry often relies on moderate process conditions.
Limitations exist in scaling up reactions with extreme parameters using traditional methods.

Purpose of the Study:

To review various approaches for achieving Novel Process Windows.
To highlight the role of microstructured reactors in enabling these windows.
To showcase examples of chemical and process-design intensification.

Main Methods:

Discussion of different routes to Novel Process Windows.
Categorization of examples based on chemical and process-design intensification.
Emphasis on microstructured reactors for managing harsh conditions.

Main Results:

Identification of multiple strategies for implementing Novel Process Windows.
Demonstration of safe operation under high temperatures, pressures, and solvent-free conditions.
Examples illustrating process simplification and integration.

Conclusions:

Novel Process Windows offer significant advantages for synthetic chemistry at various scales.
Microstructured reactors are key enablers for safely exploiting extreme process conditions.
This approach facilitates substantial chemical and process-design intensification.