Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Renal adaptation to changes in dietary phosphate during development.

S E Mulroney1, A Haramati

  • 1Department of Physiology and Biophysics, Georgetown University School of Medicine, Washington, DC 20007.

The American Journal of Physiology
|June 1, 1990
PubMed
Summary

Phosphate handling in the kidneys changes with age. Immature rats show a greater increase in phosphate reabsorption when dietary phosphate is low and a smaller decrease when it is high compared to adults.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The accumulation of IGF-I in kidneys of streptozotocin-diabetic adult rats is not associated with elevated plasma GH or IGF-I levels.

Endocrine·2010
Same author

Strengthening veterinary medical education through new international relationships: making the IAMSE connection. International Association of Medical Science Educators.

Journal of veterinary medical education·2001
Same author

Integrating complementary and alternative medicine into conventional medical education: role of basic science.

Archives of internal medicine·2001
Same author

Renal tubular sites of increased phosphate transport and NaPi-2 expression in the juvenile rat.

American journal of physiology. Regulatory, integrative and comparative physiology·2001
Same author

"Teaching physiology: filling a bucket or lighting a fire?".

The Physiologist·2000
Same author

Early hyperplastic renal growth after uninephrectomy in adult female rats.

Endocrinology·2000

Area of Science:

  • Nephrology
  • Developmental Biology
  • Mineral Metabolism

Background:

  • Phosphate homeostasis is crucial for overall health.
  • The renal tubule plays a key role in regulating phosphate levels.
  • Developmental changes in renal phosphate handling are not fully understood.

Purpose of the Study:

  • To investigate how dietary phosphate influences renal phosphate reabsorption capacity across different developmental stages.
  • To compare the adaptive responses of immature and adult rats to varying dietary phosphate intake.

Main Methods:

  • Wistar rats at three developmental stages (immature, young, adult) were fed low, normal, or high phosphate diets.
  • Renal clearance experiments were conducted to determine maximal tubular phosphate reabsorption (Max RPi/GFR).

Related Experiment Videos

  • Acute thyroparathyroidectomy was performed to isolate renal handling of phosphate.

    • Main Results:

    • Max RPi/GFR was highest in immature rats and decreased with age.
    • Immature rats exhibited a significantly larger increase in Max RPi/GFR (68%) when fed a low phosphate diet compared to adult rats (38%).
    • Immature rats showed the smallest decrease in Max RPi/GFR (-42%) when fed a high phosphate diet, compared to young (-54%) and adult (-61%) rats.

    Conclusions:

    • Renal tubular capacity for phosphate reabsorption is significantly influenced by age and dietary phosphate levels.
    • Immature rats demonstrate a more robust and adaptable tubular phosphate reabsorption capacity compared to adult rats.
    • These findings highlight developmental plasticity in renal phosphate handling, crucial for maintaining mineral balance during growth.