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Double Direct Injection of Blood into the Cisterna Magna as a Model of Subarachnoid Hemorrhage
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Cognitive domain deficits in patients with aneurysmal subarachnoid haemorrhage at 1 year

George Kwok Chu Wong1, Sandy Wai Lam, Karine Ngai

  • 1Division of Neurosurgery, Department of Surgery, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong. georgewong@surgery.cuhk.edu.hk

Journal of Neurology, Neurosurgery, and Psychiatry
|April 23, 2013
PubMed

Insights

Cognitive deficits after aneurysmal subarachnoid hemorrhage (aSAH) significantly impact 1-year functional outcomes. Multiple cognitive domain deficits are linked to poorer results and are associated with age and delayed cerebral infarction.

Area of Science:

  • Neuroscience
  • Neurology
  • Public Health

Background:

  • Cognitive domain deficits are a known complication following aneurysmal subarachnoid haemorrhage (aSAH).
  • Systematic evaluation of the impact of these deficits on 1-year outcomes remains limited.

Purpose of the Study:

  • To investigate the pattern of cognitive domain deficits in aSAH patients.
  • To determine the impact of these deficits on functional outcomes at 1 year post-ictus.

Main Methods:

  • A prospective observational study involving 168 aSAH patients (aged 21-75) admitted within 96 hours of ictus.
  • Cognitive function assessed using a domain-specific neuropsychological battery at 1-year follow-up.
  • Study registered at ClinicalTrials.gov (NCT01038193).

Main Results:

  • Prevalence of individual cognitive domain deficits ranged from 7% to 15%; 13% had two or more deficits.
  • Two or more domain deficits and the number of deficits were significantly associated with unfavorable functional outcomes (Modified Rankin Scale 3-5) and instrumental activities of daily living dependency.
  • Multiple cognitive deficits were independently associated with older age and delayed cerebral infarction.

Conclusions:

  • Cognitive domain deficits significantly worsen functional outcomes at 1 year in aSAH patients.
  • Delayed cerebral infarction is an independent risk factor for developing multiple cognitive domain deficits.
Abstract

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