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Multimodal evaluation of tissue-engineered cartilage.

Joseph M Mansour¹, Jean F Welter

¹Skeletal Research Center, Department of Biology Case Western Reserve University Cleveland, OH, 44106.

Journal of Medical and Biological Engineering

|April 23, 2013

Summary

Tissue engineering (TE) for arthritis shows promise, but donor variability hinders reproducible results. Establishing quality control release criteria based on native cartilage properties is crucial for successful TE cartilage implantation.

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Area of Science:

Biomaterials Science
Regenerative Medicine
Orthopedics

Background:

Tissue engineering (TE) offers a potential biological solution for arthritis treatment.
Current TE cartilage generation faces challenges due to significant inter- and intra-donor variability, impacting reproducibility.
Achieving mechanical and biological properties similar to native cartilage is essential for successful TE cartilage implantation.

Purpose of the Study:

To review quality control (QC) aspects for TE cartilage.
To identify target mechanical and biological properties of native cartilage for TE applications.
To discuss the current state of TE cartilage assessment and the need for non-destructive testing.

Main Methods:

Review of native articular cartilage mechanical and biological properties.

Keywords:

Cartilage Properties Testing Tissue engineering

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Overview of current tissue assessment methodologies for native and engineered cartilage.

Discussion of arguments for non-destructive testing (NDT) in TE cartilage QC.

Main Results:

Native cartilage properties serve as essential targets for TE cartilage.
Current assessment methods for TE cartilage are discussed.
The need for validated NDT methods for TE cartilage QC is highlighted.

Conclusions:

Establishing QC release criteria for TE cartilage is vital for predictable clinical outcomes.
Understanding target native cartilage properties and employing reproducible assessment methods are key.
Developing and validating non-destructive testing methods will enhance TE cartilage quality control and implantation success.