Immunohistochemistry of superoxide dismutase-1 in developing human brain
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S Takashima1, H Kuruta, T Mito
1Division of Mental Retardation and Birth Defect Research, National Institute of Neuroscience, Tokyo, Japan.
Brain & Development
|January 1, 1990
Abstract:
The developmental changes in superoxide dismutase (SOD)-1 were studied in brains ranging in age from human fetuses to adults by immunohistochemistry. SOD-positive neurons and glial cells appeared with maturation in each region, and increased progressively with gestational and postnatal age. This phenomenon implies a relationship between SOD-1 gene expression and the anti-oxidant defence mechanism in developing neurons and glia.