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Bromocriptine in the Rett syndrome.

M Zappella¹, A Genazzani, F Facchinetti

¹Department of Child Neurology and Psychiatry, Regional Hospital, Siena, Italy.

Brain & Development

|January 1, 1990

Summary

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Bromocriptine treatment showed potential benefits for Rett syndrome patients, improving communication, motor skills, and reducing repetitive behaviors. Subsequent washout periods indicated the drug

Area of Science:

Neurology
Pediatrics
Pharmacology

Background:

Rett syndrome is a rare neurodevelopmental disorder affecting girls.
Current treatments for Rett syndrome are limited, focusing on symptom management.

Purpose of the Study:

To investigate the efficacy of bromocriptine in treating Rett syndrome.
To assess the drug's impact on various clinical symptoms and neuroendocrine markers.

Main Methods:

A cohort of 13 patients with Rett syndrome received bromocriptine for six months.
A two-month washout period followed, with subsequent re-initiation of bromocriptine.
Neuroendocrine assessments (prolactin, endorphins) were conducted before and after treatment.

Main Results:

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Improvements were observed in communication, relaxation, sleep patterns, facial expressions, and vocalizations.
Reductions in hyperpnea, teeth grinding, and stereotypic hand movements were noted.
Washout led to a decline in benefits, with less pronounced effects upon re-treatment; endorphin responsiveness increased post-treatment.

Conclusions:

Bromocriptine demonstrates potential therapeutic benefits for Rett syndrome symptoms.
The drug's effects appear reversible, suggesting a direct pharmacological action.
Further research is warranted to explore bromocriptine's long-term efficacy and safety in Rett syndrome.