Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Abnormal Proliferation02:23

Abnormal Proliferation

Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the daughter...
Fibril-associated Collagen01:11

Fibril-associated Collagen

Fibril-associated collagens are a type of collagens present in the extracellular matrix with interrupted triple helices or FACIT (Fibril-associated collagens interrupted triple-helices). FACIT help connect and attach the collagen fibrils with each other as well as with other proteins of the extracellular matrix.
For example, the type II collagen fibrils in cartilage have covalently bound type IX fibril-associated collagens at regular intervals. Other types of fibril-associated collagens are...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A prospective crossover study comparing ICCS-recommended and Palmer-adjusted filling rates in children with spina bifida.

Journal of pediatric urology·2026
Same author

Risk Tier, Variant Certainty, and Real-World Care Patterns in Breast Cancer Patients with Germline Alterations in Breast Cancer Susceptibility Genes.

Cancers·2026
Same author

HOXB13, a high-risk prostate cancer gene, also confers risk for breast cancer: novel variants of clinical significance, especially in hormone-positive patients.

Journal of human genetics·2026
Same author

Association between enteral formula type and nutritional failure in critically ill children: A single-center retrospective study.

European journal of pediatrics·2026
Same author

Unilateral Lattice Corneal Dystrophy Associated With c.1864A>T Variant in the Transforming Growth Factor Beta-Induced Gene: A Rare Case Report.

Eye & contact lens·2026
Same author

Is there any difference between surgical and endoscopic interventions related to the outcome of recurrent tracheoesophageal fistulas? A systematic review.

Journal of pediatric surgery·2026

Related Experiment Video

Updated: May 12, 2026

Identifying, Diagnosing, and Grading Malignant Peripheral Nerve Sheath Tumors in Genetically Engineered Mouse Models
08:57

Identifying, Diagnosing, and Grading Malignant Peripheral Nerve Sheath Tumors in Genetically Engineered Mouse Models

Published on: May 17, 2024

Mitotically active plexiform fibrohistiocytic tumor.

Ebru Zemheri1, Seyma Ozkanlı, Serkan Senol

  • 1Department of Pathology, Istanbul Medeniyet University Goztepe Training and Research Hospital, Turkey.

Case Reports in Pathology
|April 23, 2013
PubMed
Summary

Plexiform fibrohistiocytic tumor (PFT) is a rare intermediate malignant soft tissue tumor. This case highlights a rare back region PFT in a child, emphasizing the need for complete excision and follow-up due to potential aggressive behavior.

More Related Videos

Wild-type Blocking PCR Combined with Sanger Sequencing for Detection of Low-frequency Somatic Mutation
07:17

Wild-type Blocking PCR Combined with Sanger Sequencing for Detection of Low-frequency Somatic Mutation

Published on: August 23, 2024

Multiplexed Fluorescent Immunohistochemical Staining, Imaging, and Analysis in Histological Samples of Lymphoma
07:52

Multiplexed Fluorescent Immunohistochemical Staining, Imaging, and Analysis in Histological Samples of Lymphoma

Published on: January 9, 2019

Related Experiment Videos

Last Updated: May 12, 2026

Identifying, Diagnosing, and Grading Malignant Peripheral Nerve Sheath Tumors in Genetically Engineered Mouse Models
08:57

Identifying, Diagnosing, and Grading Malignant Peripheral Nerve Sheath Tumors in Genetically Engineered Mouse Models

Published on: May 17, 2024

Wild-type Blocking PCR Combined with Sanger Sequencing for Detection of Low-frequency Somatic Mutation
07:17

Wild-type Blocking PCR Combined with Sanger Sequencing for Detection of Low-frequency Somatic Mutation

Published on: August 23, 2024

Multiplexed Fluorescent Immunohistochemical Staining, Imaging, and Analysis in Histological Samples of Lymphoma
07:52

Multiplexed Fluorescent Immunohistochemical Staining, Imaging, and Analysis in Histological Samples of Lymphoma

Published on: January 9, 2019

Area of Science:

  • Oncology
  • Pathology
  • Pediatric Surgery

Background:

  • Plexiform fibrohistiocytic tumor (PFT) is an intermediate malignant neoplasm affecting superficial soft tissues, primarily in children and young adults.
  • While typically found on upper extremities, PFTs involving the back region are rare.
  • PFTs exhibit fibrohistiocytic cytomorphology and a characteristic multinodular growth pattern.

Purpose of the Study:

  • To report a rare case of a mitotically active plexiform fibrohistiocytic tumor located on the back region of a child.
  • To underscore the importance of complete surgical excision and long-term follow-up for PFTs, regardless of location.

Main Methods:

  • Case report of a pediatric patient with a solid mass on the back.
  • Surgical excision of the tumor.
  • Histopathological examination of the excised mass, including assessment of mitotic activity.

Main Results:

  • The excised mass was diagnosed as a plexiform fibrohistiocytic tumor.
  • The tumor exhibited a higher than usual mitotic activity (6/10 HPF).
  • The tumor's location on the back region was atypical.

Conclusions:

  • Plexiform fibrohistiocytic tumors, even when rare in location like the back, can present with significant mitotic activity.
  • Complete surgical excision with clear margins and vigilant long-term follow-up are crucial for managing PFTs to monitor for recurrence and metastasis.
  • This case emphasizes the need for awareness of PFTs in diverse anatomical locations and their potential for aggressive behavior.