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Obstructing hamartomatous polyp in peutz-jeghers syndrome
Brian S Bentley1, Hassan M Hal
1Department of Radiology, Penn State Milton S. Hershey Medical Center, 100 University Drive, Hershey, PA 17033, USA.
Case Reports in Radiology
|April 23, 2013
Summary
A 53-year-old male with abdominal pain and weight loss was diagnosed with Peutz-Jeghers hamartomatous polyps. These non-cancerous growths caused an intestinal obstruction and were identified through imaging and biopsy.
Area of Science:
- Gastroenterology
- Oncology
- Genetics
Background:
- Peutz-Jeghers syndrome is a rare genetic disorder.
- It is characterized by hamartomatous polyps in the gastrointestinal tract.
- Increased risk of various cancers is associated with this syndrome.
Purpose of the Study:
- To report a case of Peutz-Jeghers syndrome presenting with intestinal obstruction.
- To highlight the diagnostic features and histological findings.
- To emphasize the importance of recognizing mucocutaneous pigmentation as a clinical sign.
Main Methods:
- Clinical presentation of a 53-year-old male with abdominal pain and weight loss.
- Physical examination revealing mucocutaneous pigmentation.
- Radiologic and endoscopic imaging to identify duodenal and bowel masses.
- Histological analysis of biopsied polyps.
Main Results:
- An obstructing mass in the duodenum and smaller masses in the bowel were identified.
- Biopsies confirmed hamartomatous polyps with architectural disorganization but no dysplasia.
- The findings were consistent with Peutz-Jeghers syndrome.
Conclusions:
- Peutz-Jeghers hamartomatous polyps can cause significant gastrointestinal issues like obstruction.
- Mucocutaneous pigmentation is a key clinical indicator for suspecting the syndrome.
- Early diagnosis and management are crucial due to cancer risks.
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