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Updated: May 12, 2026

Evaluating the Angiogenetic Properties of Ovarian Cancer Stem-Like Cells using the Three-Dimensional Co-Culture System, NICO-1
Published on: December 5, 2020
[Role of neoadjuvant chemotherapy in the advanced ovarian cancer]
Visnja Mataga1, Visnja Matković
1Zavod za radioterapiju i internisticku onkologiju, Klinika za tumore, KBC "Sestre milosrdnice", Zagreb.
Abstract:
Primary surgery is still thought as cornerstone in treating locally advanced epithelial ovarian cancer. Subsequent to surgery is usually chemotherapy. Survival of patients with advanced epithelial ovarian cancer, according to International Federation of Gynecology and Obstetrics (FIGO) stage IIIC and IV, who make over 75% of total patients with ovarian cancer is still unsatisfactory. With these patients it is often impossible to perform adequate resection of all changes in the abdomen (optimal debulking) and so is the effectiveness of chemotherapy decreased. Therefore as a possible optimal approach appears neoadjuvant chemotherapy (NAC) that leads to the decreasing of the primary tumour and possible metastasis in the abdomen. With such an approach an operation procedure is shorter and easier after 3-4 cycles of chemotherapy with a stronger possibility of optimal "debulking".
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