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Related Experiment Video

Updated: May 12, 2026

In Vivo Monitoring of Transcriptional Activity During Metabolic Transition Using a Bioluminescent Reporter in Yeast

In Vivo Monitoring of Transcriptional Activity During Metabolic Transition Using a Bioluminescent Reporter in Yeast

Published on: February 21, 2025

High levels of melatonin generated during the brewing process.

H Garcia-Moreno¹, J R Calvo, M D Maldonado

¹Department of Medical Biochemistry, Molecular Biology and Immunology, University of Seville Medical School, Sevilla, Spain.

Journal of Pineal Research

|April 24, 2013

Summary

This study reveals that barley and yeast significantly contribute melatonin to beer. Higher alcohol content correlates with greater melatonin concentrations, offering insights into beer

Keywords:

antioxidant beer brewer's yeast hops immunomodulation malt melatonin

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Light-Controlled Fermentations for Microbial Chemical and Protein Production

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Last Updated: May 12, 2026

In Vivo Monitoring of Transcriptional Activity During Metabolic Transition Using a Bioluminescent Reporter in Yeast

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Published on: February 21, 2025

Light-Controlled Fermentations for Microbial Chemical and Protein Production

Light-Controlled Fermentations for Microbial Chemical and Protein Production

Published on: March 22, 2022

Area of Science:

Food Science
Biochemistry
Brewing Science

Background:

Beer is a globally consumed beverage derived from cereals like barley and wheat.
It contains various bioactive phytochemicals and nutraceutical compounds.
Previous findings indicate significant melatonin concentrations in beer, correlating with alcohol content.

Purpose of the Study:

To investigate the specific stages of beer production where melatonin is introduced.
To identify the primary sources of melatonin enrichment during brewing.

Main Methods:

Utilized gel filtration chromatography and enzyme-linked immunosorbent assay (ELISA) for melatonin quantification.
Conducted a controlled brewing process to track melatonin levels.

Main Results:

Melatonin was found to be present in beer, with concentrations varying based on alcohol content.
The study identified key contributors to melatonin levels during the brewing process.

Conclusions:

Malted and ground barley in the early stages is a significant source of melatonin.
Yeast during the second fermentation also substantially enriches beer with melatonin.