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Updated: May 12, 2026
Microarray-based Identification of Individual HERV Loci Expression: Application to Biomarker Discovery in Prostate Cancer
Published on: November 2, 2013
The role of prostate-specific antigen in light of new scientific evidence
C Hernández1, J Morote, B Miñana
1Servicio de Urología, Hospital General Universitario Gregorio Marañón, Madrid, España.
Objective:
Review the scientific evidence acquired in recent years on Prostate-Specific Antigen (PSA).
Acquisition Of Evidence:
Analysis of the available evidence on the current role of PSA, according to a panel of experts who recorded their experience on the subject.
Summary Of The Evidence:
Currently, PSA cannot be considered solely an indicator of the presence or absence of prostate cancer. Rather, the determination of PSA assists the urologist in indicating the most appropriate treatment for a patient with benign prostatic hypertrophic (BPH), as well as in suspecting a prostatic tumour when the PSA reading increases >0,3 ng/ml, in patients treated with 5-alpha-reductase inhibitor, over the reading achieved at six months of having initiated this treatment. Moreover, PSA is a key factor in the follow-up of patients with prostate adenocarcinoma who undergo surgery, radiation therapy or minimally invasive techniques. PSA helps to define biochemical recurrence, suggest the existence of a local or distal recurrence and propose or rule out adjuvant therapies.
Conclusions:
New data on the current role of PSA in the management of patients treated for BPH and/or prostate cancer should be taken into account.
