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Updated: May 12, 2026
Multimodal Imaging of Stem Cell Implantation in the Central Nervous System of Mice
Published on: June 13, 2012
Improvement of white matter changes on neuroimaging modalities after stem cell transplant in metachromatic
Martje E van Egmond1, Petra J W Pouwels, Jaap-Jan Boelens
1Department of Child Neurology, VU University Medical Center, Amsterdam, the Netherlands.
Importance:
We sought to illustrate improvement of cerebral white matter changes in metachromatic leukodystrophy after treatment with hematopoietic stem cell transplant (HSCT).
Observations:
We conducted serial magnetic resonance imaging (MRI) and proton magnetic resonance spectroscopy (1H-MRS) as standard follow-up after HSCT with cord blood in 1 patient with juvenile metachromatic leukodystrophy diagnosed before frank degenerative symptoms developed. We measured MRI and 1H-MRS changes. The white matter changes first increased after HSCT, then decreased in relation to the pre-HSCT MRI and 1H-MRS.
Conclusions And Relevance:
Hematopoietic stem cell transplant, if performed early in metachromatic leukodystrophy, can not only stabilize but even improve cerebral white matter abnormalities. Our findings suggest a biological effect of HSCT.
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