Related Experiment Video
Updated: May 12, 2026

Corneal and Limbal Alkali Injury Induction Using a Punch-Trephine Technique in a Mouse Model
Published on: August 4, 2023
Topical proparacaine abuse resulting in evisceration
Adnan Aksoy1, Ahmet Metin Başkan, Lokman Aslan
1Department of Ophthalmology, Faculty of Medicine, Sutcu Imam University, Kahramanmaraş, Turkey.
Misuse of topical anesthetic eye drops led to severe corneal complications, including melting and perforation. This resulted in the evisceration of the patient's right eye, highlighting the dangers of anesthetic abuse.
Area of Science:
- Ophthalmology
- Corneal Disease
- Glaucoma Management
Background:
- A 72-year-old male presented with right eye pain, diagnosed with bullous keratopathy and glaucoma.
- Initial treatment included antiglaucoma medications and artificial tears, but keratopathy persisted.
Observation:
- The patient self-administered topical anesthetic eye drops instead of prescribed medication due to persistent ocular pain.
- Despite warnings, the patient continued using the anesthetic drops, leading to worsening corneal issues.
Findings:
- Persistent bullous keratopathy and elevated intraocular pressure (35 mm Hg) in the right eye.
- Corneal melting and perforation developed secondary to chronic topical anesthetic misuse.
- Evisceration of the right eye was ultimately required due to irreversible corneal damage.
Implications:
- Highlights the critical risk of corneal toxicity and perforation associated with topical anesthetic abuse.
- Underscores the importance of patient education and adherence to prescribed treatments in managing ocular conditions.
- Emphasizes the need for vigilant monitoring in cases of persistent ocular pain and non-adherence.
Related Concept Videos
Local Anesthetics: Common Agents and Their Applications
Cocaine is an ester of benzoic acid and methylecgogine. It is used to anesthetize and vasoconstrict locally. Currently, it is used primarily for topical applications. It is beneficial for surgeries on the upper respiratory tract, providing anesthesia and shrinking the mucosa. Cocaine in the form of cocaine hydrochloride is...
Local Anesthetics: Clinical Application as Epidural Anesthesia
Since epidural anesthetics can be infused through an epidural catheter, all types of drugs, including short-acting ones, can be administered. Chloroprocaine and lidocaine are examples of short and long-duration anesthetics, respectively. Bupivacaine...
Local Anesthetics: Clinical Application as Intravenous Regional Anesthesia
One of the advantages of...
Local Anesthetics: Clinical Application as Surface, Infiltration, and Conduction Block Anesthesia
Local Anesthetics: Adverse Effects
Once absorbed into the systemic circulation, local anesthetics can affect the organs that depend on the functioning of sodium...
Clinical Applications of Epidermal Stem Cells
