Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Imaging Studies for Cardiovascular System IV: CMRI

Imaging Studies for Cardiovascular System IV: CMRI

Cardiovascular magnetic resonance imaging, or CMRI, is a non-invasive diagnostic test that employs a magnetic field and radiofrequency waves to create precise images of the heart and arteries. It provides comprehensive information about cardiac anatomy, function, perfusion, and tissue characterization without ionizing radiation.IndicationsCMRI diagnoses various heart conditions, including tissue damage from heart attacks, ischemic heart disease, myocarditis, aortic issues (tears, aneurysms,...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Correction: Marchetti et al. MicroRNA-24-3p Targets Notch and Other Vascular Morphogens to Regulate Post-ischemic Microvascular Responses in Limb Muscles. <i>Int. J. Mol. Sci</i>. 2020, <i>21</i>, 1733.

International journal of molecular sciences·2026

Same author

Severe hypoxia drives loss of ST6GAL1-mediated α2,6-sialylation in the epicardial secretome impairing angiogenic activity.

Biology open·2026

Same author

Interleukin 11-Induced MicroRNAs as Functional Mediators and Circulating Biomarkers of Cardiac Fibrosis.

Circulation research·2026

Same author

Senescence-related myocardial dysfunction: keeping a young heart.

European heart journal·2026

Same author

Left and right myocardial ventricular energetics during cardioplegic ischemic arrest and reperfusion in patients undergoing cardiac surgery.

Journal of molecular and cellular cardiology·2026

Same author

Human Left Ventricle circRNA-miRNA-mRNA Network Analyses Reveal a Novel Proangiogenic Role for circNPHP1 Under Ischemic Conditions.

JACC. Basic to translational science·2026

Search research articles

Related Experiment Video

Updated: May 12, 2026

Induction of Myocardial Infarction and Myocardial Ischemia-Reperfusion Injury in Mice

Induction of Myocardial Infarction and Myocardial Ischemia-Reperfusion Injury in Mice

Published on: January 19, 2022

miRNAGE-34 induces cardiac damAGE.

Costanza Emanueli¹, Thomas Thum

¹Laboratory of Vascular Pathology and Regeneration, School of Clinical Sciences, University of Bristol, Bristol, England. costanza.emanueli@bristol.ac.uk

|April 24, 2013

Summary

MicroRNAs (miRNAs) impact gene expression and are linked to heart disease and aging. A new study identifies miR-34a as a key factor in heart aging and damage.

Area of Science:

Molecular Biology
Cardiovascular Science
Aging Research

Background:

Small non-coding microRNAs (miRNAs) are crucial regulators of gene expression across cellular systems.
miRNAs have been increasingly recognized for their roles in the pathogenesis of cardiovascular disease and the aging process.
Specific miRNAs are implicated as potential drivers or markers of age-related cardiac dysfunction.

Purpose of the Study:

To investigate the role of specific microRNAs in the context of cardiac aging.
To identify miRNAs that contribute to age-associated cellular damage and apoptosis in the heart.
To elucidate the function of miR-34a in the aging cardiovascular system.

Main Methods:

Analysis of miRNA expression profiles in aging cardiac tissues.

More Related Videos

Improved Rodent Model of Myocardial Ischemia and Reperfusion Injury

Improved Rodent Model of Myocardial Ischemia and Reperfusion Injury

Published on: March 7, 2022

Related Experiment Videos

Last Updated: May 12, 2026

Induction of Myocardial Infarction and Myocardial Ischemia-Reperfusion Injury in Mice

Induction of Myocardial Infarction and Myocardial Ischemia-Reperfusion Injury in Mice

Published on: January 19, 2022

Improved Rodent Model of Myocardial Ischemia and Reperfusion Injury

Improved Rodent Model of Myocardial Ischemia and Reperfusion Injury

Published on: March 7, 2022

Functional studies to assess the impact of miR-34a on cardiomyocyte apoptosis.

Investigation of miR-34a's contribution to overall cardiac health during aging.

Main Results:

The study identified miR-34a as a significantly upregulated miRNA in the aging heart.
Overexpression of miR-34a was found to promote apoptosis in cardiac cells.
miR-34a was characterized as a detrimental factor contributing to age-related cardiac damage.

Conclusions:

miR-34a plays a critical role in the aging process of the heart.
This microRNA acts as an aging-associated factor that promotes cell death and cardiac damage.
Targeting miR-34a may offer a therapeutic strategy for mitigating age-related cardiovascular decline.