Using impedance cardiography to detect asymptomatic cardiovascular disease in prehypertensive adults with risk
1Dermed Diagnostics Inc, 2-S 558 White Birch Lane, Wheaton, IL 60189, USA. ademarzo.dermed@att.net
Insights
Impedance cardiography (ICG) can detect cardiovascular abnormalities in prehypertensive adults over 40. This noninvasive test aids early detection of subclinical cardiovascular disease (CVD) for tailored prevention strategies.
Area of Science:
- Cardiology
- Medical Technology
- Preventive Medicine
Background:
- Early detection of cardiovascular disease (CVD) in prehypertension is crucial for preventing progression.
- Impedance cardiography (ICG) offers a noninvasive method for assessing cardiovascular function.
Purpose of the Study:
- To evaluate ICG waveform analysis with postural change for detecting CVD in asymptomatic prehypertensive adults.
- The study focused on individuals over 40 with at least two cardiovascular risk factors and no prior CVD history.
Main Methods:
- ICG was performed on 25 prehypertensive adults in standing and supine positions.
- Hemodynamic measurements (SVR, CI) and waveform analysis were used to assess vascular load and ventricular function.
- An age-matched control group of 16 healthy subjects was included for comparison.
Main Results:
- All 25 prehypertensive subjects exhibited abnormal ICG data, averaging 2.9 abnormalities per person.
- 96% showed elevated vascular load, 52% had ventricular dysfunction, and 48% had abnormal hemodynamics.
- The control group showed no elevated vascular load or ventricular dysfunction.
Conclusions:
- Prehypertensive adults over 40 with multiple risk factors present with distinct cardiovascular abnormalities.
- ICG testing can be integrated into prevention programs for early CVD detection.
- Abnormal ICG results can guide personalized treatments for subclinical CVD.
Introduction:
Early detection of cardiovascular disease (CVD) in prehypertension could initiate appropriate treatment and prevent progression. Impedance cardiography (ICG) is a noninvasive technology that can be used to assess cardiovascular function.
Objective:
This study used ICG waveform analysis with postural change to detect CVD in asymptomatic prehypertensive adults over 40 years of age with no history of CVD and at least 2 cardiovascular risk factors: cigarette smoking, poor diet, physical inactivity, central obesity, family history of premature CVD, elevated blood glucose, and dyslipidemia.
Methods:
A study group of 25 apparently healthy adults was tested by ICG in standing and supine positions. Criteria for an age-matched control group of 16 healthy subjects included an active lifestyle, no risk factor, and no history of CVD. In addition to hemodynamic measurements of systemic vascular resistance (SVR) and cardiac index (CI), ICG used SVR to assess vascular resistive load, an index of arterial compliance and a widening of the systolic waveform to assess vascular pulsatile load, and waveform analysis and measured wave amplitude to detect ventricular dysfunction.
Results:
All subjects in the study group had some abnormal ICG data, with an average of 2.9 ± 1.5 abnormalities per person. ICG indicated that 24 (96%) had elevated vascular load, 13 (52%) had some type of ventricular dysfunction, and 12 (48%) had abnormal hemodynamics. For the control group, ICG showed none (0%) with elevated vascular load, none (0%) with ventricular dysfunction, and 7 (44%) with high CI.
Conclusions:
Prehypertensives over 40 years of age with multiple risk factors have different cardiovascular abnormalities. This ICG test could be used as part of a prevention program for early detection of CVD. An abnormal ICG test could expedite the initiation of customized treatment that targets the subclinical CVD.
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