Serum proteomics in biomedical research: a systematic review

Area of Science:

• Biochemistry
• Proteomics
• Biomarker Discovery

Background:

• Proteins in serum indicate physiological or pathological states, aiding early disease diagnosis and mechanism identification.
• Serum is an accessible, cost-effective medium for disease detection, with potential to revolutionize diagnostics.
• Differentially expressed serum proteins are crucial for monitoring disease status.

Purpose of the Study:

• To review the value of serum as a diagnostic tool.
• To summarize proteomic technologies for serum protein analysis.
• To elaborate on serum proteomics for disease biomarker discovery and diagnostics.

Main Methods:

• Review of emerging proteomic techniques for global serum protein analysis.
• Analysis of serum proteome for biomarker identification.
• Discussion of applications in clinical diagnostics.

Main Results:

• Serum proteomics is recognized as an excellent diagnostic medium.
• Comprehensive human serum proteome analysis offers potential for new biomarker discovery.
• Advancements facilitate disease diagnostics through serum analysis.

Conclusions:

• Serum proteomics is a credible diagnostic tool with high potential.
• Emerging technologies enable accurate and comprehensive serum analysis.
• This field presents critical challenges and future perspectives for disease biomarker discovery.