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Updated: May 12, 2026

Chemoselective Modification of Viral Surfaces via Bioorthogonal Click Chemistry
12:31

Chemoselective Modification of Viral Surfaces via Bioorthogonal Click Chemistry

Published on: August 19, 2012

Is click chemistry attractive for separation sciences?

Audrey Marechal1, Racha El-Debs, Vincent Dugas

  • 1Institut des Sciences Analytiques, UMR CNRS 5280, Université de Lyon, Villeurbanne, France.

Journal of Separation Science
|April 24, 2013
PubMed
Summary

Click chemistry offers a novel approach to surface functionalization in liquid chromatography (LC). This review explores its application in stationary phases, enhancing chromatographic performance across various LC modes.

Keywords:
ChromatographyClick chemistryMonolithStationary phaseSurface functionalization

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Area of Science:

  • Analytical Chemistry
  • Separation Science

Background:

  • Liquid chromatography (LC) performance relies on stationary phase properties, including surface functionalization.
  • Developing advanced surface chemistries is crucial for improving chromatographic separations.
  • Traditional functionalization methods have limitations, driving the search for new techniques.

Purpose of the Study:

  • To review the application of click chemistry in chromatographic sciences.
  • To highlight the advantages of click chemistry for stationary phase development in LC.
  • To discuss the impact of clicked materials on different chromatographic modes.

Main Methods:

  • Review of scientific literature on click chemistry in chromatography.
  • Focus on the implementation of click chemistry in stationary phase design.
  • Analysis of chromatographic performance data for clicked materials.

Main Results:

  • Click chemistry provides specific, high-yield reactions compatible with aqueous media.
  • Newly developed clicked stationary phases demonstrate enhanced chromatographic properties.
  • The review details the use of these materials across various LC applications.

Conclusions:

  • Click chemistry represents a significant advancement in surface functionalization for LC.
  • The versatility of click chemistry opens new avenues for tailored stationary phase design.
  • This approach holds promise for optimizing separation performance in diverse analytical challenges.