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Updated: May 12, 2026

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Exercise Test for Evaluation of the Functional Efficacy of the Pig Cardiovascular System
Published on: May 12, 2023
Diagnostic exercise: poor performance in a racehorse.
F Giannitti1, R Petrov2, J Parker2
1California Animal Health and Food Safety (CAHFS) Laboratory System, School of Veterinary Medicine, University of California, Davis, CA, USA fgiannitti@ucdavis.edu.
Veterinary Pathology
|April 24, 2013
Summary
This study details a case of a Thoroughbred gelding with prolonged poor performance and fever, ultimately diagnosed with severe liver disease. Diagnostic findings highlight significant hepatomegaly and fibrosis, underscoring the challenges in equine liver pathology.
Area of Science:
- Veterinary Medicine
- Equine Internal Medicine
- Hepatology
Background:
- A 9-year-old Thoroughbred gelding exhibited a 97-day history of poor performance and intermittent fever.
- Clinicopathologic findings included elevated liver enzymes (γ-glutamyltransferase, alkaline phosphatase), mild hyperbilirubinemia, and leukocytosis with neutrophilia and lymphopenia.
Observation:
- Abdominal ultrasound revealed hepatomegaly with hyperechoic hepatic parenchyma and biliary distention.
- Pathological examination showed marked hepatomegaly (3.6% of body weight), firm consistency, diffuse enhanced reticular pattern, severe portal bridging, sinusoidal fibrosis, oval cell/bile duct hyperplasia, and bile stasis.
Findings:
- The case presents a complex equine liver disease with significant histopathological changes.
- Diagnostic workup involved clinicopathologic analysis and abdominal ultrasonography to identify the extent of hepatic and biliary abnormalities.
Implications:
- This case highlights the diagnostic challenges and pathological features of severe equine liver disease.
- Understanding these findings aids in the differential diagnosis and management of similar presentations in horses.
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