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Related Concept Videos

Fractures: Bone Repair01:27

Fractures: Bone Repair

Treatment for a fracture is based on the type of break, the bone affected, and the patient's age.
Minor fractures with no bone displacement are treated by immobilizing the fractured bone using a cast or splint. However, in the case of fractures with displaced bones, the broken bones are repositioned before immobilization to ensure successful healing without deformation and loss of function. The realignment of fractured bone ends is performed through a process called reduction. If the procedure...
Bone Disorders01:29

Bone Disorders

Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Flail Chest-I01:24

Flail Chest-I

Overview of Flail Chest
Flail chest is a severe and potentially life-threatening condition characterized by the fracture of three or more adjacent ribs in multiple places. It is most commonly caused by direct impacts and trauma, such as motor vehicle accidents or injuries from a steering wheel impact. It can also occur due to falls in elderly individuals with osteoporosis, or assaults involving sharp objects.
Pathophysiology
The pathophysiology of flail chest is complex, involving fractures of...
Changes in the Appendicular Skeleton with Age01:09

Changes in the Appendicular Skeleton with Age

The upper and lower limb initially develops as a small bulge called a limb bud, which appears on the lateral side of the early embryo. The upper limb bud appears near the end of the fourth week of development, with the lower limb bud appearing shortly after.
Initially, the limb buds consist of a core of mesenchyme covered by a layer of ectoderm. The ectoderm at the end of the limb bud thickens to form a narrow crest called the apical ectodermal ridge. This ridge stimulates the underlying...
Growth of Cartilage and Bone Tissue01:27

Growth of Cartilage and Bone Tissue

Chondrocytes form a temporary cartilaginous model by dividing and secreting a thick gel-like extracellular matrix. Once the chondrocytes undergo programmed cell death, osteoblasts enter the site of the cartilaginous model. The process of replacing the temporary cartilaginous model with bone in an ordered manner is called endochondral ossification. In endochondral ossification, not all of the cartilage is replaced by bone tissue. Some cartilage that performs a protective and supportive function...
The Functions of the Skeletal System01:22

The Functions of the Skeletal System

The most apparent functions of the skeletal system are support, protection, and movement. However, bone tissue also performs several other critical metabolic functions. For one, the bone matrix acts as a reservoir for a number of minerals important to the functioning of the body, especially calcium and phosphorus. These minerals, present in the bone tissue, can be released back into the bloodstream when required. Calcium ions, for example, are essential for muscle contractions and controlling...

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Related Experiment Video

Updated: May 12, 2026

A Rat Tibial Growth Plate Injury Model to Characterize Repair Mechanisms and Evaluate Growth Plate Regeneration Strategies
06:53

A Rat Tibial Growth Plate Injury Model to Characterize Repair Mechanisms and Evaluate Growth Plate Regeneration Strategies

Published on: July 4, 2017

Pathological fractures in children.

C B R De Mattos1, O Binitie, J P Dormans

  • 1Shriners Hospital for Children, Portland, 3101 SW Sam Jackson Park Road, Portland, Oregon 97239, USA.

Bone & Joint Research
|April 24, 2013
PubMed
Summary
This summary is machine-generated.

Pathological fractures in children, often caused by bone tumors, require prompt recognition and appropriate orthopedic management. Early diagnosis and a multidisciplinary approach can lead to fracture healing and limb salvage, avoiding amputation.

Keywords:
BenignBone tumourChildrenMalignancyPathological fractureSarcoma

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Tricolor Transgenic Murine Model for Studying Growth Plate Injury
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Creating Rigidly Stabilized Fractures for Assessing Intramembranous Ossification, Distraction Osteogenesis, or Healing of Critical Sized Defects
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Related Experiment Videos

Last Updated: May 12, 2026

A Rat Tibial Growth Plate Injury Model to Characterize Repair Mechanisms and Evaluate Growth Plate Regeneration Strategies
06:53

A Rat Tibial Growth Plate Injury Model to Characterize Repair Mechanisms and Evaluate Growth Plate Regeneration Strategies

Published on: July 4, 2017

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Creating Rigidly Stabilized Fractures for Assessing Intramembranous Ossification, Distraction Osteogenesis, or Healing of Critical Sized Defects
07:35

Creating Rigidly Stabilized Fractures for Assessing Intramembranous Ossification, Distraction Osteogenesis, or Healing of Critical Sized Defects

Published on: April 11, 2012

Area of Science:

  • Pediatric Orthopedics
  • Pediatric Oncology
  • Pediatric Radiology

Background:

  • Pathological fractures in children stem from diverse causes, including metabolic diseases, infections, and bone tumors.
  • Benign bone tumors like unicameral bone cysts, aneurysmal bone cysts, non-ossifying fibromas, and fibrous dysplasia are common culprits.
  • While rare, pathological fractures from primary bone malignancies necessitate rapid identification for improved patient outcomes.

Purpose of the Study:

  • To highlight the importance of recognizing and managing pathological fractures in pediatric patients.
  • To outline the diagnostic approach and treatment strategies for fractures associated with benign and malignant bone tumors in children.
  • To emphasize the potential for fracture healing and limb salvage in these cases.

Main Methods:

  • Comprehensive patient history and physical examination.
  • Radiographic assessment of plain radiographs to identify fracture and underlying bone lesions.
  • Multidisciplinary team approach for diagnosis and treatment planning.

Main Results:

  • Fractures through benign bone lesions often heal, with lesions managed concurrently or post-healing.
  • Malignant bone tumors causing pathological fractures, though rare, require prompt diagnosis and specialized care.
  • Limb salvage is a viable option, with amputation not always necessary.

Conclusions:

  • Accurate diagnosis through clinical evaluation and imaging is critical for effective management.
  • A structured, multidisciplinary approach ensures optimal care for pediatric patients with pathological fractures.
  • Successful fracture healing and limb preservation are achievable goals in most cases of pediatric pathological fractures.