Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Fractures: Bone Repair

Fractures: Bone Repair

Treatment for a fracture is based on the type of break, the bone affected, and the patient's age.
Minor fractures with no bone displacement are treated by immobilizing the fractured bone using a cast or splint. However, in the case of fractures with displaced bones, the broken bones are repositioned before immobilization to ensure successful healing without deformation and loss of function. The realignment of fractured bone ends is performed through a process called reduction. If the procedure...

Healing II: Complications

Healing II: Complications

Complications during healing arise when tissue repair is altered by local or systemic factors. These changes involve abnormal collagen deposition, altered biomechanics, and reduced vascular supply, impairing restoration of normal structure and function.Loss of FunctionScar tissue differs significantly from the original tissue it replaces. In the skin, fibrosis lacks adnexal structures such as hair follicles, sebaceous glands, and sweat glands. Their absence reduces tactile sensitivity, impairs...

Tissue Transplantation

Tissue Transplantation

Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...

Bone Formation by Intramembranous Ossification

Bone Formation by Intramembranous Ossification

Intramembranous ossification is one of the two processes involved in the development of bones within an embryo. The flat bones of the face, most of the cranial bones, and the clavicles are formed via this process. During intramembranous ossification, the bones develop directly from sheets of undifferentiated mesenchymal connective tissue.
The process begins when mesenchymal cells in the embryonic skeleton gather together and differentiate into osteogenic cells, which then develop into...

Bone Disorders

Bone Disorders

Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...

Esophageal Perforation-I: Introduction

Esophageal Perforation-I: Introduction

Esophageal perforation is a severe medical condition characterized by a breach in the integrity of the esophageal wall. This breach can occur due to various factors such as trauma, medical procedures, or underlying diseases. When the esophageal wall is compromised, it allows food, fluids, and digestive juices into the chest cavity or adjacent structures, leading to potential complications and health risks.
The location of esophageal perforation can vary, occurring anywhere along the esophagus.

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

The state of the art of osseointegration for limb prosthesis.

Biomedical engineering letters·2020

Same author

Mirna biogenesis pathway is differentially regulated during adipose derived stromal/stem cell differentiation.

Adipocyte·2018

Same author

Effectiveness of foot fasciotomies in foot and ankle trauma.

Journal of the Royal Army Medical Corps·2017

Same author

The Compress® transcutaneous implant for rehabilitation following limb amputation.

Der Unfallchirurg·2017

Same author

Link Between Clinical Predictors of Heterotopic Ossification and Histological Analysis in Combat-Injured Service Members.

The Journal of bone and joint surgery. American volume·2016

Same author

The development of a rat model to investigate the formation of blast-related post-traumatic heterotopic ossification.

The bone & joint journal·2015

Search research articles

Related Experiment Video

Updated: May 12, 2026

Direct Mouse Trauma/Burn Model of Heterotopic Ossification

Direct Mouse Trauma/Burn Model of Heterotopic Ossification

Published on: August 6, 2015

Blast injuries and heterotopic ossification.

K A Alfieri¹, J A Forsberg, B K Potter

¹Walter Reed National Military Medical Center, 8901 Rockville Pike, Bethesda, Maryland 20889, USA.

Bone & Joint Research

|April 24, 2013

Summary

Heterotopic ossification (HO) is a major challenge for combat veterans. Research is exploring early detection and new treatments for this condition, aiming to improve mobility and recovery.

Keywords:

Amputation Blast injury Combat Ectopic bone Heterotopic ossification War wounds

More Related Videos

A Coupled Experiment-finite Element Modeling Methodology for Assessing High Strain Rate Mechanical Response of Soft Biomaterials

A Coupled Experiment-finite Element Modeling Methodology for Assessing High Strain Rate Mechanical Response of Soft Biomaterials

Published on: May 18, 2015

Bone Marrow Transplantation Procedures in Mice to Study Clonal Hematopoiesis

Bone Marrow Transplantation Procedures in Mice to Study Clonal Hematopoiesis

Published on: May 26, 2021

Related Experiment Videos

Last Updated: May 12, 2026

Direct Mouse Trauma/Burn Model of Heterotopic Ossification

Direct Mouse Trauma/Burn Model of Heterotopic Ossification

Published on: August 6, 2015

A Coupled Experiment-finite Element Modeling Methodology for Assessing High Strain Rate Mechanical Response of Soft Biomaterials

A Coupled Experiment-finite Element Modeling Methodology for Assessing High Strain Rate Mechanical Response of Soft Biomaterials

Published on: May 18, 2015

Bone Marrow Transplantation Procedures in Mice to Study Clonal Hematopoiesis

Bone Marrow Transplantation Procedures in Mice to Study Clonal Hematopoiesis

Published on: May 26, 2021

Area of Science:

Orthopedics
Regenerative Medicine
Military Medicine

Background:

Heterotopic ossification (HO) significantly impairs mobility and recovery in combat-injured veterans.
Higher prevalence of HO in recent conflicts necessitates further research into its causes.
Understanding HO mechanisms is crucial for improving veteran care.

Purpose of the Study:

Investigate the complex mechanisms of HO formation.
Identify factors contributing to the increased prevalence of HO in combat veterans.
Develop strategies for early detection, risk stratification, and prophylaxis of HO.

Main Methods:

Exploring systemic and wound-specific factors in HO.
Analyzing cell lineage and neurogenic inflammation in HO development.
Testing non-invasive in vivo Raman spectroscopy for early HO detection.
Developing a wound-specific model to detect early gene transcript signatures of HO.

Main Results:

Research is elucidating complex mechanisms of HO, including systemic, local, and cellular factors.
Promising non-invasive detection methods like Raman spectroscopy are under investigation.
Early gene transcript signature detection models are being developed for HO identification.

Conclusions:

Advancements in understanding HO mechanisms are paving the way for improved veteran care.
Early detection and risk stratification are key goals for managing HO.
Novel prophylactic treatments for HO are a critical future development.