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Updated: May 12, 2026

Fabricating Superhydrophobic Polymeric Materials for Biomedical Applications
Published on: August 28, 2015
Synthesis of atactic and isotactic poly(1,2-glycerol carbonate)s: degradable polymers for biomedical and
1Department of Biomedical Engineering, Boston University, Boston, Massachusetts 02215, United States.
Abstract:
The synthesis and characterization of atactic and isotactic linear poly(benzyl 1,2-glycerol carbonate)s are reported. The poly(benzyl 1,2-glycerol carbonate)s were obtained via the ring-opening copolymerization of rac-/(R)-benzyl glycidyl ether with CO2 using [SalcyCo(III)X] complexes with high carbonate linkage selectivity and polymer/cyclic carbonate selectivity (>99%). Deprotection of the resultant polymers afforded poly(1,2-glycerol carbonate)s with a functionalizable pendant primary hydroxyl group. Poly(1,2-glycerol carbonate) showed a remarkable increase in degradation rate compared to poly(1,3-glycerol carbonate) with a t1/2 ≈ 2-3 days. These polymers fulfill an unmet need for a readily degradable biocompatible polycarbonate.
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