Related Experiment Video
Updated: May 12, 2026
Long-term Sensory Conflict in Freely Behaving Mice
Published on: February 20, 2019
Oxidative stress is not involved in motion sickness in mice
Zhi-Bin Wang1, Ping Han, Ye Tu
1Department of Pharmacology, Second Military Medical University, Shanghai, China.
Aims:
Some indirect evidences indicate a possible correlation between oxidative stress and motion sickness. The aim of this research was to investigate whether oxidative stress contributing to motion sickness in mice or not.
Methods:
We examined the mRNA levels of peroxiredoxin 6 (PRDX6), catalase, and enzyme superoxide dismutase 1 (SOD1); reactive oxygen species (ROS); and total antioxidant capacity and SOD activity in different brain regions after rotary stimulation. Mice motion sickness index was recorded after rotation when pretreated with paraquat, vitamin C, or vitamin E.
Results:
The ROS level and antioxidant capacity were both increased in cerebellum plus brainstem (CB) after rotation, a critical region determines motion sickness. However, manipulation of oxidants or antioxidants using pharmacological method in vivo had no influence on motion sickness index in mice.
Conclusion:
Oxidative stress is not involved in the development of motion sickness in mice.
Insights
This study investigated oxidative stress in motion sickness. Results show that while oxidative stress markers increase in the brainstem after rotation, antioxidants do not affect motion sickness in mice, indicating no causal link.
Area of Science:
- Neuroscience
- Biochemistry
Background:
- Indirect evidence suggests a link between oxidative stress and motion sickness.
- Understanding this relationship is crucial for developing effective treatments.
Purpose of the Study:
- To determine if oxidative stress contributes to the development of motion sickness in a mouse model.
- To investigate the role of specific oxidative stress markers in brain regions affected by motion sickness.
Main Methods:
- Assessed mRNA levels of antioxidant enzymes (PRDX6, catalase, SOD1) and measured reactive oxygen species (ROS) and antioxidant capacity in mouse brain regions post-rotation.
- Recorded motion sickness index in mice pretreated with paraquat (oxidant), vitamin C, or vitamin E (antioxidants).
Main Results:
- Rotation increased ROS levels and antioxidant capacity in the cerebellum and brainstem (CB), a key area for motion sickness.
- Pharmacological manipulation of oxidants and antioxidants did not alter the motion sickness index in mice.
Conclusions:
- Oxidative stress is not a contributing factor in the development of motion sickness in mice.
- The observed changes in oxidative stress markers in the CB region are likely a response rather than a cause of motion sickness.
More Related Videos
06:18Assessing the Autonomic and Behavioral Effects of Passive Motion in Rats using Elevator Vertical Motion and Ferris-Wheel Rotation
Published on: February 7, 2020
08:50How to Study Placebo Responses in Motion Sickness with a Rotation Chair Paradigm in Healthy Participants
Published on: December 14, 2014
