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Standardized Data Acquisition for Neuromelanin-Sensitive Magnetic Resonance Imaging of the Substantia Nigra

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Schizophrenia and frontotemporal dementia: shared causation?

Michał Harciarek¹, Dolores Malaspina, Tao Sun

¹Division of Clinical Psychology and Neuropsychology, Institute of Psychology, University of Gdansk, Poland.

International Review of Psychiatry (Abingdon, England)

|April 25, 2013

Summary

Schizophrenia and frontotemporal dementia may share genetic causes, potentially involving the same genes at different life stages. Future research should explore these genetic and cognitive links, including aberrant lateralization patterns.

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Area of Science:

Neuropsychiatry
Genetics
Cognitive Neuroscience

Background:

The link between specific genes and neuropsychiatric disorders like schizophrenia and frontotemporal dementia remains unclear.
Emerging research explores shared neurobiological and cognitive pathology across distinct disorders.
This review focuses on the potential overlap between schizophrenia and frontotemporal dementia.

Purpose of the Study:

To review evidence for an association between schizophrenia and frontotemporal dementia.
To discuss genetic and epigenetic findings relevant to both conditions.
To propose a hypothesis of shared susceptibility and common causation.

Main Methods:

Review of existing literature on schizophrenia and frontotemporal dementia.
Analysis of symptom similarity, familial co-morbidity, and neuroanatomical changes.
Examination of genetic and epigenetic data for both disorders.

Main Results:

Evidence suggests symptom overlap, familial co-morbidity, and shared neuroanatomical changes between schizophrenia and frontotemporal dementia.
Genetic and epigenetic findings indicate potential shared biological pathways.
A hypothesis of shared susceptibility for specific subgroups is proposed.

Conclusions:

Schizophrenia and frontotemporal dementia may share underlying genetic factors, with implications for disease onset timing.
Future research should investigate genetic and cognitive parallels, considering aberrant lateralization.
Understanding shared causation can inform novel therapeutic strategies for both disorders.