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Serum uric acid and metabolic risk
1Université Paris 7, UFR médicale, Assistance Publique-Hôpitaux de Paris, Hôpital Lariboisière, Fédération de Rhumatologie, Paris, France. pascal.richette@lrb.aphp.fr
Current Medical Research and Opinion
|April 25, 2013
Summary
Elevated uric acid (UA) is strongly linked to metabolic syndrome and may play a causal role. Lowering UA shows promise as a novel treatment target for preventing diabetes and other chronic diseases.
Area of Science:
- Metabolic Health
- Endocrinology
- Cardiovascular Risk Factors
Background:
- Metabolic syndrome is a cluster of conditions increasing risk for heart disease, stroke, and type 2 diabetes.
- The role of uric acid (UA) in metabolic risk and its association with metabolic syndrome remains an area of active investigation.
Purpose of the Study:
- To review current information on the role of uric acid in metabolic risk.
- To examine the link between hyperuricemia and metabolic syndrome.
Main Methods:
- Literature search of key papers using PubMed.
- Selection of articles based on relevance to the topic, as judged by the authors.
Main Results:
- Elevated uric acid is strongly associated with metabolic syndrome.
- Elevated uric acid is predictive of metabolic syndrome development.
- Emerging evidence suggests a potential causal role for uric acid in metabolic syndrome.
Conclusions:
- The traditional view of uric acid as a mere marker of metabolic syndrome may need revision.
- Lowering uric acid presents a potential novel therapeutic strategy for preventing diabetes.
- Further clinical trials are warranted to investigate the benefits of measuring and lowering serum UA for chronic disease management.
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