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Development and in vitro evaluation of slippery nanoparticles for enhanced diffusion through native mucus

Flavia Laffleur1, Fabian Hintzen, Gul Shahnaz

  • 1Department of Pharmaceutical Technology, Institute of Pharmacy, Leopold-Franzens-University of Innsbruck, Innrain 80/82, 6020 Innsbruck, Austria.

Nanomedicine (London, England)
|April 25, 2013
PubMed
Summary

Neutral nanoparticles made from poly(acrylic acid) (PAA) and poly(allylamine) (PAM) show enhanced mucus penetration. These findings highlight their potential for improved drug delivery across mucus membranes.

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