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Related Experiment Video

Updated: May 12, 2026

Simple Establishment of a Vascularized Osteogenic Bone Marrow Niche Using Pre-Cast Poly(ethylene Glycol) (PEG) Hydrogels in an Imaging Microplate

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Angiogenic factors in bone local environment.

Shek Man Chim¹, Jennifer Tickner, Siu To Chow

¹Molecular Lab, School of Pathology and Laboratory Medicine, University of Western Australia, Nedlands, WA 6009, Australia.

Cytokine & Growth Factor Reviews

|April 25, 2013

Summary

Angiogenesis is crucial for bone health and disease, involving factors like VEGF produced by bone cells. Understanding these angiogenic factors can lead to new treatments for bone disorders.

Keywords:

Angiogenesis Bone remodeling Bone remodeling compartment EGF-like

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Bioengineering of Humanized Bone Marrow Microenvironments in Mouse and Their Visualization by Live Imaging

Bioengineering of Humanized Bone Marrow Microenvironments in Mouse and Their Visualization by Live Imaging

Published on: August 1, 2017

Area of Science:

Bone Biology and Angiogenesis
Skeletal Homeostasis and Pathology

Background:

Angiogenesis is vital for bone growth, remodeling, and repair, including conditions like fracture healing and osteonecrosis.
Vascularization is essential for bone remodeling and maintaining the cartilage-subchondral bone interface.
Angiogenic factors produced by bone cells regulate endothelial cells and pericytes within the bone microenvironment.

Purpose of the Study:

To review the expression and function of angiogenic factors produced by osteoclasts, osteoblasts, and osteocytes.
To discuss the role of specific factors including VEGF, bFGF, BMP7, RANKL, and EGF-like members.
To highlight newly identified EGFL factors and their potential roles in bone angiogenesis.

Main Methods:

Review of existing literature on angiogenesis in bone.
Analysis of the expression and function of key angiogenic factors.
Discussion of cellular sources and targets of these factors within the bone remodeling compartment.

Main Results:

Osteoclasts, osteoblasts, and osteocytes produce various angiogenic factors (VEGF, bFGF, BMP7, RANKL, EGF-like family).
Newly identified EGFL factors (EGFL2-9) are present in the bone environment, suggesting novel roles in angiogenesis.
These factors are critical for both physiological bone processes and pathological conditions.

Conclusions:

Angiogenic factors are key regulators of bone vascularization and remodeling.
Understanding these factors offers potential for novel therapeutic targets and diagnostic biomarkers for bone diseases.
Further research into EGFL factors may uncover new insights into bone angiogenesis and related pathologies.