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Related Concept Videos

Traumatic Brain Injury l: Introduction01:28

Traumatic Brain Injury l: Introduction

DefinitionTraumatic brain injury, or TBI, is a disturbance of normal brain function induced by an external mechanical force, such as a direct blow to the head or a penetrating injury. It can affect both brain structure and function, producing a wide range of clinical outcomes. TBI is a heterogeneous condition, meaning its effects may differ based on the type, location, and severity of the injury.Basis of ClassificationTBI is classified based on severity, injury mechanism, or pathophysiology. In...
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Early Ischemia and Ionic ImbalanceWithin minutes of spinal cord injury, a secondary cascade begins, progressing over hours to weeks. Vascular damage reduces blood flow, causing ischemia and mitochondrial dysfunction. ATP depletion leads to ion pump failure, membrane depolarization, sodium influx, potassium efflux, and water accumulation, resulting in cellular swelling. Increased intracellular calcium further disrupts mitochondria and accelerates cellular injury.Excitotoxicity and Neuronal...
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A hemorrhagic stroke develops when a cerebral blood vessel ruptures, allowing blood to escape into the surrounding brain tissue, as in intracerebral hemorrhage (ICH), or into the subarachnoid space, as in subarachnoid hemorrhage (SAH). Because the skull is a rigid compartment, the sudden presence of extravascular blood rapidly increases intracranial pressure and compresses adjacent neural structures, leading to immediate tissue injury and impaired cerebral perfusion.Mass Effect and Primary...
Spinal Cord Injury ll: Pathophysiology01:14

Spinal Cord Injury ll: Pathophysiology

Spinal cord injury progresses through two interconnected phases: primary injury and secondary injury.Primary InjuryPrimary injury happens at the moment of trauma and involves immediate mechanical damage to the spinal cord.Compression happens when broken vertebrae, herniated discs, or accumulating blood (such as a hematoma) press directly against the spinal cord, distorting its normal shape and function. In cases of contusion, the cord is bruised by a blunt force (like penetrating injuries or...
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Vasogenic edema is a major form of cerebral edema characterized by abnormal accumulation of fluid in the brain’s extracellular space due to disruption of the blood–brain barrier (BBB). The BBB is a specialized structure composed of endothelial cells connected by tight junctions, supported by astrocytic endfeet and a basement membrane. Under normal conditions, it tightly regulates the movement of ions, proteins, and solutes between the bloodstream and brain parenchyma. When this barrier loses...
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Advanced Diffusion Imaging in The Hippocampus of Rats with Mild Traumatic Brain Injury
10:33

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Published on: August 14, 2019

Diffuse traumatic brain injury and the sensory brain.

Dasuni S Alwis1, Victoria Johnstone, Edwin Yan

  • 1Department of Physiology, Monash University, Melbourne, Vic., Australia.

Clinical and Experimental Pharmacology & Physiology
|April 25, 2013
PubMed
Summary

Traumatic brain injury can impair sensory cortex processing, leading to long-term cognitive deficits. This review explores how disordered brain processing, not peripheral damage, underlies these cognitive impairments after brain injury.

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Controlled Cortical Impact Model for Traumatic Brain Injury
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Published on: August 5, 2014

Area of Science:

  • Neuroscience
  • Neurology
  • Cognitive Science

Background:

  • Traumatic brain injury (TBI) frequently results in persistent cognitive deficits.
  • These deficits are often observed despite the absence of damage to peripheral sensory organs.

Purpose of the Study:

  • To review the consequences of TBI on the brain's cortex, particularly the sensory cortex.
  • To propose that impaired cortical sensory processing underlies long-term cognitive deficits following TBI.

Main Methods:

  • Literature review focusing on TBI effects on cortical sensory processing.
  • Analysis of the relationship between sensory processing deficits and cognitive impairments.

Main Results:

  • TBI can disrupt the brain's ability to process sensory information effectively.
  • Impaired sensory processing within the cortex is a likely contributor to cognitive dysfunction post-TBI.

Conclusions:

  • The sensory cortex plays a critical role in cognitive functions.
  • Disordered cortical processing of sensory input, rather than peripheral sensory system damage, is a key factor in TBI-related cognitive deficits.