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Related Experiment Video

Updated: May 12, 2026

The Establishment of a Murine Mandibular Molar Extraction Socket Healing Model

The Establishment of a Murine Mandibular Molar Extraction Socket Healing Model

Published on: January 13, 2023

Intra-oral PTH administration promotes tooth extraction socket healing.

S Kuroshima¹, B L Kovacic, K M Kozloff

¹Department of Biologic and Materials Sciences, School of Dentistry, University of Michigan, Ann Arbor, MI, USA.

Journal of Dental Research

|April 25, 2013

Summary

Parathyroid hormone (PTH) therapy accelerates tooth extraction socket healing. Intra-oral PTH injections are as effective as subcutaneous ones for promoting bone and soft tissue repair.

Keywords:

alveolar bone loss bone remodeling connective tissue inflammation osteogenesis wounds and injuries

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Area of Science:

Oral and Maxillofacial Surgery
Endocrinology
Regenerative Medicine

Background:

Intermittent parathyroid hormone (PTH) administration is known to increase bone mass.
The impact of PTH therapy on tooth extraction socket healing remains unexplored.

Purpose of the Study:

To investigate the effect of PTH therapy on tooth extraction socket healing in rats.
To evaluate the efficacy of intra-oral PTH injections for promoting socket healing.

Main Methods:

Surgical extraction of mandibular first molars and maxillary second molars in rats.
Intermittent subcutaneous or intra-oral administration of PTH.
Assessment of healing via micro-computed tomography and histomorphometric analysis.

Main Results:

PTH therapy significantly accelerated the overall healing process of extraction sockets.
Enhanced hard- and soft-tissue healing was observed, characterized by increased bone fill and connective tissue maturation.
Intra-oral PTH injection demonstrated comparable efficacy to subcutaneous administration in promoting socket healing.

Conclusions:

Parathyroid hormone (PTH) therapy effectively promotes tooth extraction socket healing.
Intra-oral injection is a viable and effective route for PTH administration in promoting dental wound healing.