Pragmatic exercise intervention in people with mild to moderate multiple sclerosis: a randomised controlled...

Area of Science:

• Neurology
• Rehabilitation Medicine
• Exercise Science

Background:

• People with Multiple Sclerosis (PwMS) exhibit lower physical activity levels compared to the general population.
• There is a need for practical strategies to enhance physical activity participation and confidence in PwMS.

Purpose of the Study:

• To evaluate the feasibility of a pragmatic exercise intervention for individuals with Multiple Sclerosis (PwMS).

Main Methods:

• A 10-week pragmatic exercise intervention involving supervised and home-based sessions was tested in 28 PwMS (mild-moderate disability).
• Participants were randomized to the intervention or usual care group.
• Outcomes including clinical, functional, and quality of life (MSQoL-54) were assessed at baseline, 10 weeks, and 3 months post-intervention.

Main Results:

• Low attrition rates (<15%) and high compliance (>75%) were observed.
• The intervention group demonstrated increased exercise volume, intensity, and training impulse.
• Significant improvements were noted in the physical composite score (MSQoL-54) at 10 weeks (P=0.050) and readiness to exercise at 3 months (P=0.003) compared to usual care.

Conclusions:

• The pragmatic exercise intervention is feasible for PwMS.
• Further research is warranted to determine the long-term effects of this intervention on physical activity behaviors in PwMS.