Relationship between CCR2-V64I polymorphism and cancer risk: a meta-analysis
Yuyun Huang1, Huilong Chen, Jianmiao Wang
1Department of Respiratory Diseases, Tongji Hospital, Key Lab. of Pulmonary Diseases of Health Ministry, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Gene
|April 25, 2013
Summary
The CCR2-V64I polymorphism is linked to a higher risk of developing various cancers. This meta-analysis confirms a significant association between this genetic variant and increased cancer susceptibility.
Area of Science:
- Genetics
- Oncology
- Molecular Biology
Background:
- The CCR2-V64I polymorphism has been investigated for its role in various cancers.
- Previous studies yielded conflicting results regarding the association between CCR2-V64I polymorphism and cancer risk.
Purpose of the Study:
- To conduct a meta-analysis to determine the overall cancer risk associated with the CCR2-V64I polymorphism.
- To clarify the conflicting findings from individual studies.
Main Methods:
- Systematic electronic searches of PubMed and EMBASE databases were performed.
- Included studies focused on the association between the CCR2-V64I variant and cancer.
- Odds ratios (OR) with 95% confidence intervals (95% CI) were calculated to assess the strength of the association.
Main Results:
- Sixteen studies comprising 2661 cancer patients and 5801 controls were analyzed.
- A significant overall association was found between CCR2-V64I polymorphism and cancer risk (OR=1.84).
- Subgroup analyses revealed significant associations with bladder, cervical, and oral cancers, as well as increased risk in European and Asian populations.
Conclusions:
- The CCR2-V64I polymorphism is suggested to contribute to an increased risk of cancer.
- This meta-analysis provides robust evidence supporting the link between CCR2-V64I polymorphism and cancer susceptibility.
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