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Updated: May 12, 2026

An Open-Source Normothermic Perfusion System Designed for Research Scientists
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An Open-Source Normothermic Perfusion System Designed for Research Scientists

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Differences in perfusion CT parameter values with commercial software upgrades: a preliminary report about algorithm

Maria Antonietta Mazzei1, Nevada Cioffi Squitieri, Eleonora Sani

  • 1Department of Human Pathology and Oncology, Section of Radiological Sciences, University of Siena, Siena.

Acta Radiologica (Stockholm, Sweden : 1987)
|April 25, 2013
PubMed
Summary

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Software upgrades for computed tomographic perfusion (CTp) imaging significantly alter measurements. Version 4D demonstrated more stable and reliable results compared to earlier versions, crucial for consistent oncologic therapy response evaluation.

Area of Science:

  • Radiology and Imaging Science
  • Oncologic Imaging
  • Medical Software Development

Background:

  • Computed tomographic perfusion (CTp) imaging offers functional insights for evaluating oncologic patient therapy response.
  • Consistency and reproducibility of CTp software measurements are essential for reliable clinical application.

Purpose of the Study:

  • To assess the impact of commercial software upgrades on the consistency and stability of CTp imaging algorithms.
  • To compare three versions of the same CTp software platform.

Main Methods:

  • Calculated blood volume (BV), blood flow (BF), mean transit time (MTT), and permeability surface area product (PS) using repeated measurements (n=1119).
  • Utilized CT perfusion software versions 3.0, 4.0, and 4D, with time density curve truncation and fixed regions of interest (ROI).
Keywords:
Perfusion imagingmultidetector computed tomographyoncologysoftware

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  • Employed Kolmogorov-Smirnov tests for pairwise software version comparisons and analyzed parameter variations for stability.

    • Main Results:

    • Significant differences in parent distributions were observed for approximately 80% of the 72 measured parameters across the three software versions.
    • Complete agreement between versions was rare, occurring in only one or two cases for specific comparisons.
    • CT Perfusion 4D consistently yielded the lowest standard deviation for all parameters and temporal intervals.

    Conclusions:

    • Different CTp software versions produce varying perfusion measurements, impacting clinical interpretation.
    • The Perfusion 4D version exhibits a stable deconvolution algorithm, suggesting more reliable and reproducible measurements for oncologic imaging.