Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Drugs that Stabilize Microtubules

Drugs that Stabilize Microtubules

Microtubules are dynamic structures that undergo cycles of catastrophe and rescue. The microtubules play a central role in cell division by forming the spindle apparatus for segregating the chromosomes. This makes them ideal targets for regulating dividing cells in tumors and malignant cancer cells. Microtubule stabilizing drugs help stabilize the microtubule formation and promote its polymerization. Paclitaxel was the first microtubule stabilizing agent used as anticancer drug in chemotherapy...

Site-Targeted Drug Delivery Systems: Polymeric Carriers

Site-Targeted Drug Delivery Systems: Polymeric Carriers

Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Self-Assembling Aromatic Peptide Amphiphile Fibers for Multivalent Display of Enzymatically Linked Antigenic Proteins.

ACS applied materials & interfaces·2025

Same author

Peptide Materials.

Biomacromolecules·2025

Same author

Drug-Inspired Design of Supramolecular Polymers for Enhanced Drug Loading and Sustained Therapeutic Release.

ACS nano·2025

Same author

Effective communication with JCR editors in the peer review process.

Journal of controlled release : official journal of the Controlled Release Society·2025

Same author

Balancing Chemical and Supramolecular Stability in OEGylated Supramolecular Polymers for Systemic Drug Delivery.

Journal of the American Chemical Society·2025

Same author

Self-Assembling Peptides, Conjugates, and Mimics: A Versatile Platform for Materials and Beyond.

Accounts of chemical research·2025

Search research articles

Related Experiment Video

Updated: May 12, 2026

Development of a Microfluidics-Based Approach for Investigating Microtubule Polymer Mechanics

Development of a Microfluidics-Based Approach for Investigating Microtubule Polymer Mechanics

Published on: May 30, 2025

Supramolecular filaments containing a fixed 41% paclitaxel loading.

Ran Lin¹, Andrew G Cheetham, Pengcheng Zhang

¹Department of Chemical and Biomolecular Engineering, and Institute for NanoBioTechnology, The Johns Hopkins University, 3400 N Charles Street, Baltimore, MD 21218, USA.

Chemical Communications (Cambridge, England)

|April 25, 2013

Summary

Researchers developed paclitaxel drug amphiphiles that self-assemble into supramolecular filaments. These filaments show effective cytotoxicity against cancer cell lines, similar to free paclitaxel.

More Related Videos

Formulation of Diblock Polymeric Nanoparticles through Nanoprecipitation Technique

Formulation of Diblock Polymeric Nanoparticles through Nanoprecipitation Technique

Published on: September 20, 2011

A Facile and Efficient Approach for the Production of Reversible Disulfide Cross-linked Micelles

A Facile and Efficient Approach for the Production of Reversible Disulfide Cross-linked Micelles

Published on: December 23, 2016

Related Experiment Videos

Last Updated: May 12, 2026

Development of a Microfluidics-Based Approach for Investigating Microtubule Polymer Mechanics

Development of a Microfluidics-Based Approach for Investigating Microtubule Polymer Mechanics

Published on: May 30, 2025

Formulation of Diblock Polymeric Nanoparticles through Nanoprecipitation Technique

Formulation of Diblock Polymeric Nanoparticles through Nanoprecipitation Technique

Published on: September 20, 2011

A Facile and Efficient Approach for the Production of Reversible Disulfide Cross-linked Micelles

A Facile and Efficient Approach for the Production of Reversible Disulfide Cross-linked Micelles

Published on: December 23, 2016

Area of Science:

Biomedical Engineering
Materials Science
Drug Delivery

Background:

Paclitaxel is a widely used chemotherapy drug.
Drug delivery systems are crucial for improving therapeutic efficacy and reducing side effects.
Self-assembly offers a promising strategy for creating novel drug delivery nanostructures.

Purpose of the Study:

To design and synthesize a paclitaxel drug amphiphile capable of self-assembly.
To characterize the self-assembled supramolecular structures.
To evaluate the cytotoxic efficacy of the self-assembled filaments.

Main Methods:

Rational design of a paclitaxel drug amphiphile.
Characterization of self-assembly into supramolecular filaments using microscopy and spectroscopy.
In vitro cytotoxicity assays against various cancer cell lines.

Main Results:

Successful self-assembly of the designed amphiphile into well-defined supramolecular filaments.
Achieved a fixed paclitaxel loading of 41% within the filaments.
Demonstrated effective cytotoxicity against multiple cell lines, comparable to free paclitaxel.

Conclusions:

The rationally designed paclitaxel amphiphile self-assembles into functional supramolecular filaments.
These filaments represent a promising new platform for paclitaxel drug delivery.
The self-assembled system exhibits potent anticancer activity in vitro.