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How to help the skin cope with glycoxidation
Clinical Chemistry and Laboratory Medicine
|April 25, 2013
Summary
Plant extracts effectively inhibit protein glycation and associated oxidative stress, offering a promising approach to prevent skin aging and its damaging effects.
Area of Science:
- Dermatology and Cosmetology
- Biochemistry
- Molecular Biology
Background:
- Protein glycation, the reaction of sugars with proteins, forms advanced glycation end products (AGEs).
- Glycation linked with oxidative stress is termed 'glycoxidation', contributing to skin aging.
- Inhibiting glycoxidation is vital for preventing age-related skin damage.
Purpose of the Study:
- To screen plant extracts for antiglycation and anti-glycoxidation properties.
- To evaluate the efficacy of plant extracts in preventing skin aging.
- To identify plant-derived compounds that protect skin proteins from glycation damage.
Main Methods:
- Assessed glycation inhibition on human skin proteins (collagen, elastin, albumin) and reconstructed skin models.
- Evaluated oxidative stress using copper-induced LDL oxidation, UV irradiation of glycated dermis, and fibroblast activation.
- Conducted clinical tests to measure UV-induced oxidative stress.
Main Results:
- Several plant extracts demonstrated significant reduction in glycation effects on skin proteins.
- One plant extract notably inhibited various forms of oxidative stress linked to protein glycation.
- Antioxidant-rich plant extracts protected human skin from glycoxidation damage.
Conclusions:
- Plant extracts can mitigate the harmful impacts of glycation on human skin.
- Specific plant extracts, rich in antioxidants, effectively shield skin from glycoxidation.
- These findings support the use of plant extracts in anti-aging skincare formulations.
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