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Chemical-Induced Skin Carcinogenesis Model Using Dimethylbenz[a]Anthracene and 12-O-Tetradecanoyl Phorbol-13-Acetate (DMBA-TPA)
Published on: December 19, 2019
[Viruses as agents inducing cutaneous neoplasms]
1Facultad de Medicina Alberto Hurtado, Universidad Peruana Cayetano Heredia, Lima, Perú. fbravopuccio@gmail.com
Revista Peruana De Medicina Experimental Y Salud Publica
|April 25, 2013
Summary
Viruses like human papilloma virus (HPV) and human herpes virus type 8 cause various skin cancers. Understanding these viral oncogenesis pathways offers new avenues for antiviral drug therapies.
Area of Science:
- Oncology
- Virology
- Dermatology
Context:
- The link between viruses and skin cancers (cutaneous neoplasms) has been recognized for over a century.
- Current research often focuses on genetic and molecular aspects of cancer, potentially overlooking viral etiologies.
Purpose:
- To review the role of various viruses in the development of cutaneous neoplasms.
- To highlight the classification of virus-induced skin cancers into solid tumors and lymphoproliferative disorders.
- To emphasize the potential of antiviral therapies in cancer treatment.
Summary:
- Human papilloma virus (HPV), human herpes virus type 8 (HHV-8), and Merkel cell polyomavirus are associated with solid cutaneous tumors.
- Human T-lymphotropic virus type I (HTLV-1) and Epstein Barr virus (EBV) are linked to lymphoproliferative disorders with cutaneous manifestations, often presenting diagnostic challenges.
- Viral infections are a significant cause of neoplasms, necessitating consideration in cancer research and treatment strategies.
Impact:
- Recognizing viral roles in skin cancer can improve diagnostic accuracy, especially for challenging lymphoproliferative disorders.
- This understanding opens new therapeutic possibilities, including the development of targeted antiviral drugs for cancer treatment.
- Integrates virology into the broader landscape of cancer research, complementing genetic and molecular approaches.
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