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Gender modulates the aging effects on different patterns of early repolarization
Yen-Chou Chen1, Jen-Hung Huang, Yung-Kuo Lin
1Division of Cardiovascular Medicine, Department of Internal Medicine, Wan Fang Hospital, Taipei Medical University, 111 Hsin-Lung Road, Sec. 3, Taipei 116, Taipei, Taiwan.
Heart and Vessels
|April 25, 2013
Summary
Gender influences how early repolarization (ER) patterns change with age. Elderly males showed less anterior ER, while both elderly males and females had more inferior ER compared to younger groups.
Area of Science:
- Cardiology
- Electrocardiography
- Gerontology
Background:
- Distinct early repolarization (ER) patterns are linked to ventricular fibrillation and sudden cardiac death.
- Aging significantly impacts cardiovascular physiology, potentially altering ECG findings.
Purpose of the Study:
- To investigate if biological sex modulates the age-related changes in specific early repolarization patterns.
- To analyze the prevalence and distribution of anterior, inferior, and lateral ER across different age groups and genders.
Main Methods:
- A retrospective analysis of 12-lead electrocardiograms from 2247 individuals (1077 males, 1170 females).
- Participants were categorized into young (≤44 years), middle-aged (45-64 years), and elderly (≥65 years) groups.
- Prevalence and location of early repolarization patterns were assessed and compared across age and gender strata.
Main Results:
- Early repolarization was present in 24.2% of subjects; single-location ER occurred less frequently in lateral leads (2.1%) compared to anterior (7.8%) or inferior (8.6%) leads.
- Inferior ER was more prevalent in older individuals.
- In males, anterior ER decreased with age, while both elderly males and females exhibited increased inferior ER compared to younger cohorts.
Conclusions:
- Gender significantly modulates the aging effects on the occurrence of anterior and inferior early repolarization patterns.
- These findings highlight sex-specific cardiovascular aging processes related to repolarization.
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