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Is the prevalence of pre-eclampsia affected by HIV/AIDS? A retrospective case-control study
V M S Kalumba1, J Moodley, T D Naidoo
1Department of Obstetrics and Gynaecology, Pietermaritzburg Complex of Academic Hospitals; Women's Health and HIV Research Group, Department of Obstetrics and Gynaecology, University of KwaZulu-Natal, Durban, South Africa. vitakal@yahoo.fr
Objective:
To evaluate the rate of HIV/AIDS (and CD4 levels) in women with pre-eclampsia compared to that of a control group.
Methods:
This was a retrospective case-control study in a tertiary and regional hospital in South Africa. We reviewed the hospital records of women who had delivered in these hospitals between 1 January 2008 and 30 June 2010. The records of women with pre-eclampsia during the study period were analysed. Their HIV infection rate was compared to that of a control group consisting of normotensive healthy pregnant women.
Results:
Among 492 cases of pre-eclampsia, 130 (26.4%) were HIV infected. In the control group, 183/500 (36.6%) were HIV infected (p = 0.001, OR = 0.62, 95% CI: 0.47-0.82). After adjustment to match the difference in maternal age and parity, the rate of HIV/AIDS was lower in the pre-eclamptic group than in the control group (p = 0.005, OR = 0.658).
Conclusion:
The rate of HIV/AIDS was significantly lower in women with pre-eclampsia than in normotensive healthy pregnant women.
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