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Related Concept Videos

Detailed Structure and Function of Lymph Nodes01:23

Detailed Structure and Function of Lymph Nodes

Lymph nodes are bean-shaped structures that cluster along the lymphatic vessels in the inguinal, axillary, and cervical regions. Each node is divided into compartments by a capsule that extends trabeculae inward.
From a histological perspective, lymph nodes can be split into two main areas: the superficial cortex and the deep medulla. The outer cortex is populated by dendritic cells, macrophages, and B lymphocytes, which are densely packed into follicles. When these B-lymphocytes are presented...
Lymphatic Vessels and Lymph Transport01:16

Lymphatic Vessels and Lymph Transport

Lymphatic vessels, known as lymphatics, are crucial in transporting lymph from peripheral tissues to our venous system. This process begins with lymph entering through tiny capillaries that branch through tissues. These capillaries have unique features such as larger diameters, thinner walls, and a distinctive one-way valve system formed by overlapping endothelial cells.
This one-way system allows fluids, solutes, and even pathogens to enter but prevents their return to the intercellular spaces.
Development of the Lymphatic System01:15

Development of the Lymphatic System

The development of lymphatic tissues and vessels in embryonic life begins around the fifth week. These structures originate from the mesoderm layer, with lymph sacs emerging from developing veins.
The first lymph sacs to form are the paired jugular lymph sacs located at the junction of the internal jugular and subclavian veins. From these sacs, lymphatic capillary plexuses extend to the thorax, upper limbs, neck, and head, eventually forming lymphatic vessels. Each jugular lymph sac maintains a...

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Related Experiment Video

Updated: May 12, 2026

Blocking Lymph Flow by Suturing Afferent Lymphatic Vessels in Mice
05:59

Blocking Lymph Flow by Suturing Afferent Lymphatic Vessels in Mice

Published on: May 14, 2020

Dynamics of lymphatic regeneration and flow patterns after lymph node dissection.

Katrin S Blum1, Steven T Proulx, Paola Luciani

  • 1Institute of Pharmaceutical Sciences, Swiss Federal Institute of Technology, ETH Zurich, Wolfgang Pauli-Str. 10, HCI H303, 8093, Zurich, Switzerland. blum.katrin@gmx.de

Breast Cancer Research and Treatment
|April 25, 2013
PubMed
Summary

Less invasive surgeries like sentinel lymph node biopsy (SLNB) preserve lymphatic function. Extensive surgeries, such as axillary lymph node dissection (ALND), can cause lymphatic damage and rerouting via new vessels.

More Related Videos

A Murine Tail Lymphedema Model
04:38

A Murine Tail Lymphedema Model

Published on: February 10, 2021

Related Experiment Videos

Last Updated: May 12, 2026

Blocking Lymph Flow by Suturing Afferent Lymphatic Vessels in Mice
05:59

Blocking Lymph Flow by Suturing Afferent Lymphatic Vessels in Mice

Published on: May 14, 2020

A Murine Tail Lymphedema Model
04:38

A Murine Tail Lymphedema Model

Published on: February 10, 2021

Area of Science:

  • Vascular biology
  • Surgical oncology
  • Lymphedema research

Background:

  • Understanding lymphatic regeneration post-surgery is crucial for lymphedema prevention and treatment.
  • Alterations in lymphatic flow immediately after surgical trauma remain poorly understood.

Purpose of the Study:

  • To investigate lymphatic function and regeneration following surgical trauma mimicking sentinel lymph node biopsy (SLNB) and axillary lymph node dissection (ALND).
  • To assess the impact of surgical invasiveness on lymphatic drainage and the development of collateral vessels.

Main Methods:

  • Lymphatic function was assessed in mice for 4 weeks post-surgery using near-infrared imaging.
  • Surgical models included popliteal lymph node (LN) removal (SLNB-like) or LN and fat pad removal (ALND-like).

Main Results:

  • SLNB-like surgery generally did not alter lymphatic drainage.
  • ALND-like surgery resulted in impaired lymphatic drainage, including vessel rupture, dermal backflow, and collateral vessel formation draining to the inguinal LN.
  • Development and maturation of collateral lymphatic vessels were observed after extensive trauma.

Conclusions:

  • Minimally invasive surgery helps prevent lymphatic decompensation.
  • Extensive surgical trauma can induce the formation of functional collateral lymphatic vessels that reroute lymph flow.
  • Findings may inform strategies for preventing and treating post-surgical lymphedema.