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Updated: May 12, 2026
06:01
A Genetically Engineered Mouse Model of Sporadic Colorectal Cancer
Published on: July 6, 2017
Mouse models of Kras-mutant colorectal cancer: valuable GEMMs for drug testing?
Federica Di Nicolantonio1, Alberto Bardelli
1Department of Oncology, University of Torino, Torino, Italy. federica.dinicolantonio@unito.it
Abstract:
The development of effective therapies for colorectal cancer depends on the ability of preclinical models to faithfully recapitulate the molecular and biologic behavior of human tumors. This study reports on the characterization of colorectal genetically engineered mouse models and their derivative cell lines carrying wild-type or oncogenic Kras with concomitant Apc and p53 loss.
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Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
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The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...