Related Experiment Video
Updated: May 12, 2026
09:25
Establishment of Cancer Stem Cell Cultures from Human Conventional Osteosarcoma
Published on: October 14, 2016
Osteosarcoma of the mobile spine
1Cooperative Osteosarcoma Study Group (COSS), Pediatrics 5 (Oncology, Hematology, Immunology; Gastroenterology, Rheumatology, General Pediatrics), Klinikum Stuttgart--Olgahospital, Stuttgart, Germany. coss@olgahospital-stuttgart.de
Summary
High-grade osteosarcomas of the mobile spine are rare but treatable. Complete surgical resection, chemotherapy, and potentially radiotherapy offer a comparable prognosis to appendicular osteosarcomas.
Area of Science:
- Oncology
- Orthopedic Surgery
- Medical Research
Background:
- High-grade osteosarcomas of the mobile spine are rare tumors.
- This study investigates the characteristics and outcomes of these rare spinal tumors.
Purpose of the Study:
- To analyze patient-, tumor-, and treatment-related variables for high-grade osteosarcomas of the mobile spine.
- To determine the outcome and survival rates for patients diagnosed with mobile spine osteosarcomas.
Main Methods:
- Retrospective analysis of 20 patients diagnosed with high-grade osteosarcomas of the mobile spine since 1977.
- Evaluation of patient demographics, tumor characteristics, treatment modalities (surgery, chemotherapy, radiotherapy), and patient outcomes.
Main Results:
- The median age of patients was 29 years, with thoracic and lumbar spine being the most frequent sites.
- Most patients (17/20) had nonmetastatic disease at diagnosis. Treatment involved surgery and chemotherapy for all, with 13 receiving radiotherapy.
- Five-year overall and event-free survival rates were 60% and 43%, respectively. Age <40, nonmetastatic disease, and complete remission were predictors of better overall survival.
Conclusions:
- Osteosarcomas of the mobile spine are rare entities.
- Complete surgical resection combined with chemotherapy and potentially radiotherapy may lead to prognoses comparable to appendicular osteosarcomas.
- Multidisciplinary treatment approaches are crucial for optimizing outcomes in these rare spinal tumors.
Related Concept Videos
02:49Cancer Therapies
Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
01:09Spongy Bone
All bones comprise an outer layer of compact bone, and an interior made up of spongy bone tissue, also called cancellous or trabecular bone. In long bones, spongy bone tissue is mainly found in the interior of the epiphyses (broad ends of the bone).
Spongy bone is more porous, and less dense compared to compact bone. It is composed of concentric lamellae that are arranged irregularly to form the trabecular network. In some bones, the spaces between trabeculae contain red marrow, where...
Spongy bone is more porous, and less dense compared to compact bone. It is composed of concentric lamellae that are arranged irregularly to form the trabecular network. In some bones, the spaces between trabeculae contain red marrow, where...
01:29Bone Disorders
Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
01:03Rous Sarcoma Virus (RSV) and Cancer
Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand RNA genome. Its genome consists of four main open...
RSV is a retrovirus that contains two copies of a plus-strand RNA genome. Its genome consists of four main open...