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Preliminary feasibility, acceptability, and efficacy of an innovative adherence intervention for children with newly
Avani C Modi1, Shanna M Guilfoyle, Joseph Rausch
1Division of Behavioral Medicine and Clinical Psychology, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, USA. avani.modi@cchmc.org
Insights
A family-tailored adherence intervention (AI) improved medication adherence in children with new-onset epilepsy. This approach shows promise for managing pediatric epilepsy and requires further study in larger groups.
Area of Science:
- Pediatric Neurology
- Clinical Pharmacy
- Behavioral Medicine
Background:
- Nonadherence to antiepileptic drugs (AEDs) is a significant challenge in pediatric epilepsy management.
- Poor adherence can lead to treatment failure, increased seizures, and adverse health outcomes.
- Family involvement is crucial for improving adherence in pediatric populations.
Purpose of the Study:
- To evaluate the acceptability and feasibility of a family-tailored adherence intervention (AI).
- To assess the preliminary efficacy of the AI in improving AED adherence in children with new-onset epilepsy.
- To compare the AI with Treatment-As-Usual (TAU) in a randomized controlled trial.
Main Methods:
- A randomized controlled trial involving 30 children with new-onset epilepsy and their caregivers.
- Baseline adherence monitoring using electronic monitors.
- Randomization of participants with adherence <90% to either the AI group or TAU group.
- The AI group received four intervention sessions over two months.
Main Results:
- Eight families were randomized (4 to AI, 4 to TAU).
- Families reported the AI as feasible and acceptable.
- Preliminary data indicated improved adherence in the AI group compared to baseline.
Conclusions:
- A family-tailored adherence intervention shows promise for improving AED adherence in pediatric epilepsy.
- The intervention is perceived as feasible and acceptable by participating families.
- Larger-scale studies are warranted to confirm the efficacy of this AI in pediatric epilepsy.
Objective:
To report acceptability, feasibility, and preliminary efficacy from a randomized controlled trial of a family-tailored adherence intervention (AI) targeting nonadherence to antiepileptic drugs in pediatric new-onset epilepsy.
Method:
30 children with new-onset epilepsy (7.2 ± 3.1 years old, 47% male) and their caregivers participated. At baseline, participants were given adherence electronic monitors. After a 1-month run-in period, participants with good adherence (≥90%) were monitored. Participants with adherence <90% were randomized to the AI or Treatment-As-Usual (TAU) group. The AI group received four adherence promotion intervention sessions over >2 months. Follow-up adherence data were collected.
Results:
8 families were randomized (AI, n = 4; TAU, n = 4). Families perceived AI to be feasible and acceptable. Preliminary results demonstrated that the AI group had improved adherence from baseline to post-test.
Conclusions:
A family-tailored AI appears promising and needs to be tested with a larger pediatric epilepsy sample.
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