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Related Experiment Video

Updated: May 12, 2026

Bergmeyer Glucose Quantification for Microbiological Samples

Bergmeyer Glucose Quantification for Microbiological Samples

Published on: January 17, 2025

Glucose variability.

F John Service¹

¹Mayo College of Medicine, Mayo Clinic, Rochester, Minnesota, USA. service.john@ mayo.edu

|April 25, 2013

Summary

This summary is machine-generated.

Glucose variability may worsen diabetes complications more than average glucose levels. Intermittent high blood sugar increases oxidative stress, a key factor in diabetes complications.

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Last Updated: May 12, 2026

Bergmeyer Glucose Quantification for Microbiological Samples

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Characterization of Metabolic Status in Nonhuman Primates with the Intravenous Glucose Tolerance Test

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Published on: April 6, 2022

Area of Science:

Endocrinology
Metabolic Research
Diabetes Complications

Background:

Oxidative stress is implicated in diabetes complications.
Intermittent hyperglycemia may induce greater oxidative stress than sustained hyperglycemia.
Glucose variability is a potential contributor to diabetes pathogenesis.

Purpose of the Study:

To explore the role of glucose variability in diabetes complications.
To differentiate the impact of glucose variability from glycemic exposure.

Main Methods:

Utilizing comprehensive glycemia recordings.
Developing methods to measure glucose variability.
Calculating glucose variability independent of time to avoid confounding with glycemic exposure.

Main Results:

Oxidative stress is heightened during intermittent hyperglycemia.
Glucose variability measurement requires comprehensive data.
Time-independent calculation is crucial for accurate variability assessment.

Conclusions:

Glucose variability, particularly intermittent hyperglycemia, may drive diabetes complications via oxidative stress.
Accurate measurement of glucose variability is essential for understanding its role in diabetes.