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Generation of Retinal Organoids from Healthy and Retinal Disease-Specific Human-Induced Pluripotent Stem Cells
Published on: December 9, 2022
Central and peripheral retina arise through distinct developmental paths
Sara J Venters1, Takashi Mikawa, Jeanette Hyer
1Department of Neurosurgery, University of California San Francisco, San Francisco, California, United States of America.
Plos One
|April 25, 2013
Summary
This study reveals two distinct origins for the neural retina in chick embryos. Central and peripheral retina arise from separate optic vesicle regions, impacting our understanding of eye development and disease.
Area of Science:
- Developmental biology
- Ophthalmology
- Embryology
Background:
- Mature eye tissues exhibit a precise linear organization from central to peripheral.
- The developmental origins of this topographical arrangement within the optic vesicle are not well understood.
Purpose of the Study:
- To investigate the derivation of mature eye tissues from the optic vesicle in chick embryos.
- To identify the specific origins of central and peripheral neural retina during embryogenesis.
Main Methods:
- Utilized a targeted vital labeling strategy in chick embryos.
- Performed fate mapping of the optic vesicle to trace tissue origins.
Main Results:
- Uncovered two distinct origins for the neural retina.
- Demonstrated that the central neural retina originates from the posterior optic vesicle.
- Showed the peripheral retina derives from the distal optic vesicle, sharing origins with other peripheral tissues.
Conclusions:
- Identified two discrete retinal sub-domains, central and peripheral, during embryogenesis.
- Provides a foundational framework for understanding functional and disease processes in retinal tissues.
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